ArticleJournal of neurophysiology2015
Intrinsic excitability of human motoneurons in biceps brachii versus triceps brachii.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Corticospinal excitability is higher during synchronous vs asynchronous arm cycling.European journal of applied physiology · 2026Article
- Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults.The Journal of physiology · 2026Article
- Differences in Hebbian stimulation effects between biceps and triceps brachii in humans.Journal of neurophysiology · 2025Article
- Effects of fatigue on motor unit characteristics in isometric elbow contractions across age groups.Frontiers in neuroscience · 2025Article
- Centrally mediated responses to NMES are influenced by muscle group and stimulation parameters.Scientific reports · 2024Article
- A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns.Journal of neural engineering · 2023Article
- Differences in psychological readiness for return to sport after anterior cruciate ligament injury is evident in thigh musculature motor unit characteristics.BMJ open sport & exercise medicine · 2023Article
- Effects of reciprocal inhibition and whole-body relaxation on persistent inward currents estimated by two different methods.The Journal of physiology · 2022Article
- Neuromotor control associates with muscle weakness observed with McArdle sign of multiple sclerosis.Annals of clinical and translational neurology · 2022Article
- A computational approach for generating continuous estimates of motor unit discharge rates and visualizing population discharge characteristics.Journal of neural engineering · 2022Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
- Firing rate trajectories of human occipitofrontalis motor units in response to triangular voluntary contraction intensity.Experimental brain research · 2021Article
- Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans.Journal of neurophysiology · 2021Article
- Distinct Corticospinal and Reticulospinal Contributions to Voluntary Control of Elbow Flexor and Extensor Muscles in Humans with Tetraplegia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Differences in estimated persistent inward currents between ankle flexors and extensors in humans.Journal of neurophysiology · 2020Article
- Motor unit contributions to activation reduction and torque steadiness following active lengthening: a study of residual torque enhancement.Journal of neurophysiology · 2020Article
- Plantarflexion force is amplified with sensory stimulation during ramping submaximal isometric contractions.Journal of neurophysiology · 2020Article
- Impact of parameter selection on estimates of motoneuron excitability using paired motor unit analysis.Journal of neural engineering · 2020Article
- Nonlinear Input-Output Functions of Motoneurons.Physiology (Bethesda, Md.) · 2020Review
- Exploiting cervicolumbar connections enhances short-term spinal cord plasticity induced by rhythmic movement.Experimental brain research · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The intrinsic excitability of spinal motoneurons is mediated in part by the presence of persistent inward currents (PICs), which amplify synaptic input and promote self-sustained firing. Studies using animal models have shown that PICs are greater in extensor motoneurons over flexor motoneurons, but this difference has not yet been demonstrated in humans. The primary objective of this study was to determine whether a similar difference exists in humans by recording from motor units in biceps and triceps brachii during isometric contractions. We compared firing rate profiles of pairs of motor units, in which the firing rate of the lower-threshold "control" unit was used as an indicator of common drive to the higher-threshold "test" unit. The estimated contribution of the PIC was calculated as the difference in firing rate of the control unit at recruitment versus derecruitment of the test unit, a value known as the delta-F (ΔF). We found that ΔF values were significantly higher in triceps brachii (5.4 ± 0.9 imp/s) compared with biceps brachii (3.0 ± 1.4 imp/s; P < 0.001). This difference was still present even after controlling for saturation in firing rate of the control unit, rate modulation of the control unit, and differences in recruitment time between test and control units, which are known to contribute to ΔF variability. We conclude that human elbow flexor and extensor motor units exhibit differences in intrinsic excitability, contributing to different neural motor control strategies between muscle groups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.