ArticleDevelopmental neurobiology2015
Ear manipulations reveal a critical period for survival and dendritic development at the single-cell level in Mauthner neurons.
Article in Developmental neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Prevalence and practices of immunofluorescent cell image processing: a systematic review.Frontiers in cellular neuroscience · 2023Pooled it
- Sponge bHLH Gene Expression inInternational journal of molecular sciences · 2025Article
- Article
- Article
- Vestibular Influence on Vertebrate Skeletal Symmetry and Body Shape.Frontiers in systems neuroscience · 2021Review
- Topologically correct central projections of tetrapod inner ear afferents require Fzd3.Scientific reports · 2019Article
- A New Model for Congenital Vestibular Disorders.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution.Developmental biology · 2018Review
- Transplantation of Ears Provides Insights into Inner Ear Afferent Pathfinding Properties.Developmental neurobiology · 2018Article
- Ear transplantations reveal conservation of inner ear afferent pathfinding cues.Scientific reports · 2018Article
- Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear.Developmental neurobiology · 2017Article
- Gene, cell, and organ multiplication drives inner ear evolution.Developmental biology · 2017Review
- A method for detailed movement pattern analysis of tadpole startle response.Journal of the experimental analysis of behavior · 2017Article
- Delayed Otolith Development Does Not Impair Vestibular Circuit Formation in Zebrafish.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Sensing External and Self-Motion with Hair Cells: A Comparison of the Lateral Line and Vestibular Systems from a Developmental and Evolutionary Perspective.Brain, behavior and evolution · 2017Review
- Evolution and Development of the Inner Ear Efferent System: Transforming a Motor Neuron Population to Connect to the Most Unusual Motor Protein via Ancient Nicotinic Receptors.Frontiers in cellular neuroscience · 2017Review
- Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation.Frontiers in neural circuits · 2017Article
- Neuroanatomical Tracing Techniques in the Ear: History, State of the Art, and Future Developments.Methods in molecular biology (Clifton, N.J.) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Second-order sensory neurons are dependent on afferents from the sense organs during a critical period in development for their survival and differentiation. Past research has mostly focused on whole populations of neurons, hampering progress in understanding the mechanisms underlying these critical phases. To move toward a better understanding of the molecular and cellular basis of afferent-dependent neuronal development, we developed a new model to study the effects of ear removal on a single identifiable cell in the hindbrain of a frog, the Mauthner cell. Ear extirpation at various stages of Xenopus laevis development defines a critical period of progressively-reduced dependency of Mauthner cell survival/differentiation on the ear afferents. Furthermore, ear removal results in a progressively decreased reduction in the number of dendritic branches. Conversely, addition of an ear results in an increase in the number of dendritic branches. These results suggest that the duration of innervation and the number of inner ear afferents play a quantitative role in Mauthner cell survival/differentiation, including dendritic development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.