ReviewDrug delivery and translational research2015
Clinical translation of controlled protein delivery systems for tissue engineering.
Review in Drug delivery and translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- The application of growth factors in bone tissue engineering delivery systems and collaborative innovation strategies.Annals of medicine · 2026Review
- Advanced engineering strategies for biomaterial scaffolds application in tendon-bone interface regeneration.Burns & trauma · 2026Review
- Therapeutic Controlled Release Strategies for Human Osteoarthritis.Advanced healthcare materials · 2025Review
- Biomaterials for Protein Delivery: Opportunities and Challenges to Clinical Translation.Micromachines · 2024Review
- Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels.Gels (Basel, Switzerland) · 2022Review
- Ultrasound-Responsive Hydrogels for On-Demand Protein Release.ACS applied bio materials · 2022Article
- Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications.International journal of molecular sciences · 2022Article
- Local delivery strategies to restore immune homeostasis in the context of inflammation.Advanced drug delivery reviews · 2021Review
- Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair.Bioactive materials · 2021Review
- Advances in Growth Factor Delivery for Bone Tissue Engineering.International journal of molecular sciences · 2021Review
- Protein-Based Nanohydrogels for Bioactive Delivery.Frontiers in chemistry · 2021Review
- Current and future trends in periodontal tissue engineering and bone regeneration.Plastic and aesthetic research · 2021Article
- Inflammation, Bone Healing and Osteonecrosis: From Bedside to Bench.Journal of inflammation research · 2020Review
- Recent Progress in the Construction of Functional Artificial Bone by Cytokine-Controlled Strategies.Chinese medical journal · 2018Review
- Biomimetic Approaches for Bone Tissue Engineering.Tissue engineering. Part B, Reviews · 2017Review
- Silica Nanoparticles for Intracellular Protein Delivery: a Novel Synthesis Approach Using Green Fluorescent Protein.Nanoscale research letters · 2017Article
- Designing hydrogels for controlled drug delivery.Nature reviews. Materials · 2016Article
- Inflammation, fracture and bone repair.Bone · 2016Review
- Biodegradable Polymer Membranes Applied in Guided Bone/Tissue Regeneration: A Review.Polymers · 2016Review
- Review of various treatment options and potential therapies for osteonecrosis of the femoral head.Journal of orthopaedic translation · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Strategies that utilize controlled release of drugs and proteins for tissue engineering have enormous potential to regenerate damaged organs and tissues. The multiple advantages of controlled release strategies merit overcoming the significant challenges to translation, including high costs and long, difficult regulatory pathways. This review highlights the potential of controlled release of proteins for tissue engineering and regenerative medicine. We specifically discuss treatment modalities that have reached preclinical and clinical trials, with emphasis on controlled release systems for bone tissue engineering, the most advanced application with several products already in clinic. Possible strategies to address translational and regulatory concerns are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.