ReviewLearning & memory (Cold Spring Harbor, N.Y.)2015
Principles of designing interpretable optogenetic behavior experiments.
Review in Learning & memory (Cold Spring Harbor, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 126 citations in OpenAlex.
- Protocol for optogenetic stimulation of cells under physical confinement.STAR protocols · 2026Article
- Val109 and Ile170 contribute to channel function in Guillardia theta-derived anion channelrhodopsins.Scientific reports · 2026Article
- Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.Nature communications · 2025Article
- Overcoming off-target optical stimulation-evoked cortical activity in the mouse brainiScience · 2024Article
- A Systematic Review to Compare Electrical, Magnetic, and Optogenetic Stimulation for Peripheral Nerve Repair.Journal of hand surgery global online · 2024Review
- Reducing maladaptive behavior in neuropsychiatric disorders using network modification.Frontiers in psychiatry · 2024Article
- Impact of volume and expression time in an AAV-delivered channelrhodopsin.Molecular brain · 2023Article
- A novel task to investigate vibrotactile detection in mice.PloS one · 2023Article
- Understanding the aging hypothalamus, one cell at a time.Trends in neurosciences · 2022Review
- Learning from inhibition: Functional roles of hippocampal CA1 inhibition in spatial learning and memory.Current opinion in neurobiology · 2022Review
- Optogenetics at the presynapse.Nature neuroscience · 2022Review
- Article
- Optogenetics: A new tool for cancer investigation and treatment.BioImpacts : BI · 2022Article
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors.Cell reports · 2021Article
- Remote control of neural function by X-ray-induced scintillation.Nature communications · 2021Article
- Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Photochemical control of bacterial gene expression based onChemical science · 2021Article
- Fiberless Optogenetics.Advances in experimental medicine and biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Over the last decade, there has been much excitement about the use of optogenetic tools to test whether specific cells, regions, and projection pathways are necessary or sufficient for initiating, sustaining, or altering behavior. However, the use of such tools can result in side effects that can complicate experimental design or interpretation. The presence of optogenetic proteins in cells, the effects of heat and light, and the activity of specific ions conducted by optogenetic proteins can result in cellular side effects. At the network level, activation or silencing of defined neural populations can alter the physiology of local or distant circuits, sometimes in undesired ways. We discuss how, in order to design interpretable behavioral experiments using optogenetics, one can understand, and control for, these potential confounds.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.