ArticleScientific reports2015
Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 46 citations in OpenAlex.
- Anticancer Secondary Metabolites Produced by Fungi: Potential and Representative Compounds.International journal of molecular sciences · 2025Review
- An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement.Applied biochemistry and biotechnology · 2025Review
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
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- Bioactive Microbial Metabolites in Cancer Therapeutics: Mining, Repurposing, and Their Molecular Targets.Current microbiology · 2022Review
- Sulfur-Containing Compounds from Endophytic Fungi: Sources, Structures and Bioactivities.Journal of fungi (Basel, Switzerland) · 2022Review
- Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review.Molecules (Basel, Switzerland) · 2022Review
- 4,6'-Anhydrooxysporidinone fromBiomolecules · 2021Article
- Copper-catalyzed aerobic oxidative radical alkoxycyclization of tryptamines to access 3-alkoxypyrroloindolines.RSC advances · 2021Article
- Cytotoxic and antimicrobial indole alkaloids from an endophytic fungusRSC advances · 2019Article
- Article
- Endophytic Fungus Isolated FromFrontiers in oncology · 2018Article
- Structural Diversity and Biological Activities of the Cyclodipeptides from Fungi.Molecules (Basel, Switzerland) · 2017Review
- Fungal endophyte-derived Fritillaria unibracteata var. wabuensis: diversity, antioxidant capacities in vitro and relations to phenolic, flavonoid or saponin compounds.Scientific reports · 2017Article
- Inhibition of biofilm in Bacillus amyloliquefaciens Q-426 by diketopiperazines.World journal of microbiology & biotechnology · 2016Article
- Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification.Scientific reports · 2016Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diketopiperazines are important secondary metabolites of the fungi with variety bioactivities. Several species belonging to genus Chaetomium produce compounds of this class, such as chetomin. To identify new antitumor agents, secondary metabolites of fungus Chaetomium sp 88194 were investigated and three new indole diketopiperazines, Chaetocochins G (1), Oidioperazines E (2) and Chetoseminudin E (3), along with two known compounds Chetoseminudins C (4) and N-acetyl-β-oxotryptamine (5), were obtained. Chaetocochins G and Chetoseminudin E were recrystallized in CHCl3 containing a small amount of MeOH, and their structures with absolute configuration were established by spectroscopic data interpretation and single-crystal X-ray diffraction analysis. The absolute configuration of Oidioperazines E was defined by comparing of experimental and calculated electronic circular dichroism spectra. These isolates were also evaluated the anticancer activity, and Chaetocochins G displayed more potent cytotoxicity in MCF-7 cells than the common chemotherapeutic agent (5-fluorouracil) associated with G2/M cell cycle arrest. More importantly, Chaetocochins G induced cell apoptotic death via caspase-3 induction and proteolytic cleavage of poly (ADP-ribose) polymerase, concomitantly with increased Bax and decreased Bcl-2 expression. Our findings suggested that indole diketopiperazines from endophytic Chaetomium sp 88194 may be potential resource for developing anti-cancer reagents.
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