ArticleLung2015
Influence of pulmonary hypertension on survival in advanced lung disease.
Article in Lung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- A Congestive Hemodynamic Footprint Is Associated With Worse Clinical Outcomes in Lung Transplant Recipients.Pulmonary circulation · 2026Article
- Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Detection of severe pulmonary hypertension based on computed tomography pulmonary angiography.The international journal of cardiovascular imaging · 2021Article
- Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers.The AAPS journal · 2020Article
- Demographics and Outcomes of Pulmonary Hypertension Patients in United States Emergency Departments.The western journal of emergency medicine · 2020Article
- A stepwise composite echocardiographic score predicts severe pulmonary hypertension in patients with interstitial lung disease.ERJ open research · 2018Article
- Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients: a single-institution experience.Journal of thoracic disease · 2018Article
- Pulmonary hypertension: the importance of correctly diagnosing the cause.European respiratory review : an official journal of the European Respiratory Society · 2016Review
- Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization,Therapeutic advances in respiratory diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffects of pulmonary hypertension (PH) in advanced lung disease remain unclear.
methodsThe United Network for Organ Sharing database was queried from 1987 to 2013 to assess survival lung transplant candidates to determine influence of PH in advanced lung disease. Thresholds included mean pulmonary artery pressure ≥ 25 mmHg (mild PH) and 35 mmHg (severe PH).
resultsOf 12,405 listed possible candidates, 10,158 were used for univariate analysis, 7050 for Kaplan-Meier (KM) function, 6196 for multivariate Cox models, and 5328 (mild PH) and 1910 (severe PH) for propensity score matching (PSM). For mild and severe PH, univariate revealed that PH was associated with survival difference (HR = 1.530, 95% CI 1.416, 1.654, p < 0.001) and (HR = 2.033, 95% CI 1.851, 2.232, p < 0.001), respectively. KM function curves demonstrated a significant difference for mild PH (Log-rank test: Chi square (df = 1): 117.76, p < 0.0001) and severe PH (Log-rank test: Chi square (df = 1): 230.91, p < 0.0001). Multivariate Cox models also found a significant increased risk for death for mild PH (HR = 1.750, 95% CI 1.606, 1.907, p < 0.001) and severe PH (HR = 2.088, 95% CI 1.879, 2.319, p < 0.001). PSM confirmed this increased risk for death for mild PH (HR = 1.695, 95% CI 1.502, 1.914, p < 0.001) and severe PH (HR = 1.976, 95% CI 1.641, 2.379, p < 0.001).
conclusionsPH is associated with significant increased risk for death in patients with advanced lung disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.