ArticleHypertension research : official journal of the Japanese Society of Hypertension2015
Genetic variations in the vitamin-D receptor (VDR) gene in preeclampsia patients in the Chinese Han population.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- A plethora of laboratory protocols for vitamin D receptor (VDR) gene variants detection: a systematic review of associations with hypertensive disorders of pregnancy.BMC pregnancy and childbirth · 2025Pooled it
- Association betweenPeerJ · 2023Pooled it
- Vitamin D metabolic loci and preeclampsia risk in multi-ethnic pregnant women.Physiological reports · 2018Pooled it
- Endothelial nitric oxide synthase gene G894T polymorphism and risk assessment for pregnancy-induced hypertension: evidence from 11 700 subjects.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Pooled it
- Dysregulation and gene polymorphisms of Vitamin D receptor: its implications in lipid metabolic disorders.Molecular biology reports · 2025Review
- Interplay between vitamin D status, vitamin D receptor gene variants and preeclampsia risk in Ghanaian women: A case-control study.PloS one · 2024Article
- Impact of vitamin D binding protein (GC) and vitamin D receptor (VDR) gene polymorphism on the risk of developing preeclampsia.Biochemistry and biophysics reports · 2023Article
- The Significance ofDiagnostics (Basel, Switzerland) · 2021Article
- The association of MOV10 polymorphism and expression levels with preeclampsia in the Chinese Han population.Molecular genetics & genomic medicine · 2021Article
- Comparative risks and predictors of preeclamptic pregnancy in the Eastern, Western and developing world.Biochemical pharmacology · 2020Review
- Association between vitamin D receptor gene polymorphisms and idiopathic hypocitraturia in a Chinese Bai population.Urolithiasis · 2019Article
- Glucocorticoid exposure induces preeclampsia via dampening 1,25-dihydroxyvitamin DHypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Vitamin D Reduces Oxidative Stress-Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts.The Journal of clinical endocrinology and metabolism · 2017Article
- Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have indicated that vitamin D deficiency is linked to a risk of preeclampsia (PE). The aim of our study was to investigate the association between genetic variations in the vitamin-D receptor (VDR) gene and the susceptibility to PE in the Chinese Han population. We examined the genotypes VDR rs2228570, rs11568820 and rs1544410 in 402 PE patients and 554 normal pregnant women in the third trimester by TaqMan allelic discrimination real-time polymerase chain reaction. The clinical data of the individuals were collected to enable genotype-phenotype analysis. A significant statistical difference in the genotypic frequencies of rs2228570 between cases and controls was found (χ(2)=13.750, P=0.001). The G allele was the risk factor for the risk of PE (χ(2)=9.456, P=0.002, OR=1.137, 95% CI 1.111-1.610). There was no difference in the genotypic and allelic distributions of rs11568820 and rs1544410 between the two groups (P> 0.05). Our results provide evidence for a possible link between VDR and the development of PE in the Chinese Han population.
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