ArticleDiabetic foot & ankle2015
Staphylococcus aureus small colony variants in diabetic foot infections.
Article in Diabetic foot & ankle, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Small-colony variants of Staphylococcus aureus: hidden threat in chronic and recurrent infections.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Antimicrobial Resistance in Diabetic Foot Infections in Latin America and the Caribbean: A Systematic Review and Meta-Analysis (1980-2025).International journal of microbiology · 2026Review
- Characterization ofInfection and drug resistance · 2025Article
- Phenotypic Variation inAntibiotics (Basel, Switzerland) · 2024Review
- Review
- Subpopulations in Strains ofAntibiotics (Basel, Switzerland) · 2023Review
- Synchrotron-Radiation-Based Fourier Transform Infrared Microspectroscopy as a Tool for the Differentiation between Staphylococcal Small Colony Variants.Antibiotics (Basel, Switzerland) · 2022Article
- Worsening Glycemia Increases the Odds of Intermittent but Not Persistent Staphylococcus aureus Nasal Carriage in Two Cohorts of Mexican American Adults.Microbiology spectrum · 2022Article
- Characteristics of Staphylococcus aureus small colony variants isolated from wound specimen of a tertiary care hospital in China.Journal of clinical laboratory analysis · 2022Article
- Emergence of Thymidine-Dependent Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Patients in Southern Brazil.Microbiology spectrum · 2021Article
- Long-Term Intrahost Evolution ofFrontiers in microbiology · 2021Article
- Clinical and surgical characteristics of infected diabetic foot ulcers in a tertiary hospital of Mexico.Diabetic foot & ankle · 2017Article
- Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections.Clinical microbiology reviews · 2016Review
- Phenotypic and Genotypic Characteristics of Small Colony Variants and Their Role in Chronic Infection.Microbiology insights · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background : Staphylococcus aureus (S. aureus) is one of the major pathogens causing chronic infections. The ability of S. aureus to acquire resistance to a diverse range of antimicrobial compounds results in limited treatment options, particularly in methicillin-resistant S. aureus (MRSA). A mechanism by which S. aureus develops reduced susceptibility to antimicrobials is through the formation of small colony variants (SCVs). Infections by SCVs of S. aureus are an upcoming problem due to difficulties in laboratory diagnosis and resistance to antimicrobial therapy. Methods : A prospective study was performed on 120 patients diagnosed with both type 2 diabetes mellitus and infected diabetic foot ulcers. The study was carried out from July 2012 to December 2013 in Hospital General de Mexico. The samples were cultured in blood agar, mannitol salt agar, and MacConkey agar media, and incubated at 37°C in aerobic conditions. Results : We describe the first known cases of diabetic foot infections caused by MRSA-SCVs in patients diagnosed with type 2 diabetes mellitus and infected diabetic foot ulcers. In all of our cases, the patients had not received any form of gentamicin therapy. Conclusions : The antibiotic therapy commonly used in diabetic patients with infected diabetic foot ulcers fails in the case of MRSA-SCVs because the intracellular location protects S. aureus-SCVs from the host's defenses and also helps them resist antibiotics. The cases studied in this article add to the spectrum of persistent and relapsing infections attributed to MRSA-SCVs and emphasizes that these variants may also play a relevant role in diabetic foot infections.
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