Trial reportJournal of behavioral medicine2015
Chronic pain and comorbid mental health conditions: independent associations of posttraumatic stress disorder and depression with pain, disability, and quality of life.
Trial report in Journal of behavioral medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 3 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Pooled it
- Management of chronic musculoskeletal pain in veterans: a systematic review.Acta bio-medica : Atenei Parmensis · 2021Pooled it
- Posttraumatic Stress Disorder and Justice Involvement Among Military Veterans: A Systematic Review and Meta-Analysis.Journal of traumatic stress · 2020Pooled it
- Gender differences in PTSD severity and pain outcomes: Baseline results from the LAMP trial.PloS one · 2024Trial
- An Examination of Chronic Pain Indices and the Updated Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental-Disorders-Fifth Edition.Military medicine · 2021Trial
- Guidance for simultaneous treatment of chronic pain and PTSD: a Delphi study.Journal of behavioral medicine · 2026Article
- In reply to the letter to the editor regarding "National mental health burden in adults with spinal deformity: a propensity-matched analysis using the All of Us Research Program".Spine deformity · 2026Article
- Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.The journal of pain · 2026Article
- Integrating care for chronic pain and PTSD: A qualitative exploration of staff and patient perspectives.Psychological services · 2026Article
- Do Injury, Depression, and PTSD Mediate the Relationships Between Latent Profiles of Cumulative Lifetime Violence and Chronic Pain Disability in Men?Research in nursing & health · 2026Article
- Scoping review of risk factors, cognitive and mental health effects, and interventions for chronic pain among military veterans.Discover mental health · 2026Review
- National mental health burden in adults with spinal deformity: a propensity-matched analysis using the All of Us Research Program.Spine deformity · 2026Article
- "It's probably like a web": complex relationships between pain and mental health among bisexual+ women with chronic pain.Frontiers in psychiatry · 2026Article
- Why do you think you still have pain? Individuals' beliefs on the biopsychosocial factors that contribute to their chronic musculoskeletal pain: a qualitative exploration.BMC musculoskeletal disorders · 2025Article
- Longitudinal analysis of adjustment to civilian life and self-rated mental health using the Life After Service Survey.Journal of military, veteran and family health · 2025Article
- Antidepressants and the endogenous opioid system.Biochemical pharmacology · 2025Review
- Providers' Role in Building Patient Buy-In for Treating Chronic Pain and PTSD: Veterans' Perspectives on Interactions with Providers.Journal of general internal medicine · 2025Article
- Evaluating pain management in the Gaza Strip's conflict-affected hospitals: a prospective observational study.BMC emergency medicine · 2025Observational
- Article
- Genome-wide by trait interaction analyses with neuroticism reveal chronic pain-associated depression as a distinct genetic subtype.Translational psychiatry · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both posttraumatic stress disorder (PTSD) and depression are highly comorbid with chronic pain and have deleterious effects on pain and treatment outcomes, but the nature of the relationships among chronic pain, PTSD, and depression has not been fully elucidated. This study examined 250 Veterans Affairs primary care patients with moderate to severe chronic musculoskeletal pain who participated in a randomized controlled pain treatment trial. Baseline data were analyzed to examine the independent associations of PTSD and major depression with multiple domains of pain, psychological status, quality of life, and disability. PTSD was strongly associated with these variables and in multivariate models, PTSD and major depression each had strong independent associations with these domains. PTSD demonstrated similar relationships as major depression with psychological, quality of life, and disability outcomes and significant but somewhat smaller associations with pain. Because PTSD and major depression have independent negative associations with pain, psychological status, quality of life, and disability, it is important for clinicians to recognize and treat both mental disorders in patients with chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.