ArticleDrug delivery and translational research2013
Zein/polycaprolactone electrospun matrices for localised controlled delivery of tetracycline.
Article in Drug delivery and translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Plant-Derived Zein as an Alternative to Animal-Derived Gelatin for Use as a Tissue Engineering Scaffold.Advanced nanobiomed research · 2024Article
- An in vitro and ex vivo wound infection model to test topical and systemic treatment with antibiotics.Journal of applied microbiology · 2022Article
- Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(Pharmaceutics · 2022Article
- Vibrational and fluorescence spectroscopy to study gluten and zein interactions in complex dough systems.Current research in food science · 2022Article
- Three-dimensional mesenchymal stem cell laden scaffold of icariin sustained-release for bone regeneration.Turkish journal of biology = Turk biyoloji dergisi · 2022Article
- Preparation and characterisation of zein/polyphenol nanofibres for nerve tissue regeneration.IET nanobiotechnology · 2019Article
- Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release.Pharmaceutics · 2019Review
- Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications.Pharmaceutics · 2018Review
- Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery.Pharmaceutics · 2018Review
- Electrospun Zein/PCL Fibrous Matrices Release Tetracycline in a Controlled Manner, Killing Staphylococcus aureus Both in Biofilms and Ex Vivo on Pig Skin, and are Compatible with Human Skin Cells.Pharmaceutical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the controlled release of the antibiotic tetracycline (Tet) from triple-layered (3L) electrospun matrices consisting of zein or a zein/PCL blend, where the drug was loaded into the central layer with the two outer layers acting as diffusion barriers. These fibrous matrices successfully encapsulated Tet and efficiently inhibited the growth of a clinical isolate, the methicillin-resistant Staphylococcus aureus strain MRSA252, as demonstrated in a modified Kirby-Bauer disc assay over 5 days. Whilst untreated zein fibres are unstable in an aqueous environment, rapidly shrinking due to plasticisation and film formation, blending zein with PCL stabilised the electrospun matrices and prevented them from shrinking. These 3L formulations display sustained antibiotic release and provide a proof of concept for zein-based polymeric matrices as wound dressings to treat or prevent bacterial infection. This is the first demonstration of the controlled release of a clinically used antibiotic from electrospun zein-based matrices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.