ArticlePloS one2015
A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic and Predictive Applications of Functional Near-Infrared Spectroscopy for Major Depressive Disorder: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Brain grey matter volume alterations associated with antidepressant response in major depressive disorder.Scientific reports · 2017Pooled it
- Individualized fMRI connectivity defines signatures of antidepressant and placebo responses in major depression.Molecular psychiatry · 2023Trial
- Frontal haemodynamic responses in depression and the effect of electroconvulsive therapy.Journal of psychopharmacology (Oxford, England) · 2019Trial
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- A High-Accuracy and Easy-Use Differential Diagnosis Method of Bipolar Disorder Depressive Phase and Major Depressive Disorder Using a Wearable Near-Infrared Spectroscopy.Bipolar disorders · 2026Article
- The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.European archives of psychiatry and clinical neuroscience · 2026Article
- Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy.Frontiers in psychiatry · 2026Article
- Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.Scientific reports · 2025Article
- Antidepressant Treatment Response Prediction With Early Assessment of Functional Near-Infrared Spectroscopy and Micro-RNA.IEEE journal of translational engineering in health and medicine · 2025Article
- Assessment of Brain Function After 240 Days Confinement Using Functional Near Infrared Spectroscopy.IEEE open journal of engineering in medicine and biology · 2025Article
- The Relationship between Depression Severity and Prefrontal Hemodynamic Changes in Adolescents with Major Depression Disorder: A Functional Near-infrared Spectroscopy Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Pilot Study of Cerebral Hemodynamics in Depressive Patient Under Electroconvulsive Therapy.Neuropsychiatric disease and treatment · 2024Article
- The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders.Scientific reports · 2022Article
- rTMS Therapy Reduces Hypofrontality in Patients With Depression as Measured by fNIRS.Frontiers in psychiatry · 2022Article
- Integration of the Cortical Haemodynamic Response Measured by Functional Near-Infrared Spectroscopy and Amino Acid Analysis to Aid in the Diagnosis of Major Depressive Disorder.Diagnostics (Basel, Switzerland) · 2021Article
- Task and Non-task Brain Activation Differences for Assessment of Depression and Anxiety by fNIRS.Frontiers in psychiatry · 2021Article
- The Changes in Concentration of Cerebral Oxygenated Hemoglobin During Single Event-Related Japanese Shiritori Task in Patients With Major Depression Disorder: Comparison With Healthy Subjects.Frontiers in psychiatry · 2021Article
- Postpartum Depression Is Associated With Altered Neural Connectivity Between Affective and Mentalizing Regions During Mother-Infant Interactions.Frontiers in global women's health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have indicated the potential clinical use of near infrared spectroscopy (NIRS) as a tool in assisting the diagnosis of major depressive disorder (MDD); however, it is still unclear whether NIRS signal changes during cognitive task are state- or trait-dependent, and whether NIRS could be a neural predictor of treatment response. Therefore, we conducted a longitudinal study to explore frontal haemodynamic changes following antidepressant treatment in medication-naïve MDD using 52-channel NIRS. This study included 25 medication-naïve individuals with MDD and 62 healthy controls (HC). We performed NIRS scans before and after antidepressant treatment and measured changes of [oxy-Hb] activation during a verbal fluency task (VFT) following treatment. Individuals with MDD showed significantly decreased [oxy-Hb] values during a VFT compared with HC in the bilateral frontal and temporal cortices at baseline. There were no [oxy-Hb] changes between pre- and post-antidepressant treatment time points in the MDD cohort despite significant improvement in depressive symptoms. There was a significant association between mean [oxy-Hb] values during a VFT at baseline and improvement in depressive symptoms following treatment in the bilateral inferior frontal and middle temporal gyri in MDD. These findings suggest that hypofrontality response to a VFT may represent a potential trait marker for depression rather than a state marker. Moreover, the correlation analysis indicates that the NIRS signals before the initiation of treatment may be a biological marker to predict patient's clinical response to antidepressant treatment. The present study provides further evidence to support a potential application of NIRS for the diagnosis and treatment of depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.