Evidence map›Paper›PMID 25786196›Full record

ArticleBrain connectivity2015

Effect of Repetitive Transcranial Magnetic Stimulation on fMRI Resting-State Connectivity in Multiple System Atrophy.

Ying-hui Chou, Hui You, Han Wang, Yan-ping Zhao, Bo Hou, Nan-kuei Chen, Feng Feng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain connectivity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  7. Examining the Role of Lateral Parietal Cortex in Emotional Distancing Using TMS.Cognitive, affective & behavioral neuroscience · 2020
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  19. Resting-state Functional MRI in Parkinsonian Syndromes.Movement disorders clinical practice · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ying-hui Chou1 Brain Imaging and Analysis Center, Duke University Medical Center , Durham, North Carolina.
Hui You3 Department of Radiology, Peking Union Medical College Hospital , Beijing, China .
Han Wang4 Department of Neurology, Peking Union Medical College Hospital , Beijing, China .
Yan-ping Zhao3 Department of Radiology, Peking Union Medical College Hospital , Beijing, China .
Bo Hou3 Department of Radiology, Peking Union Medical College Hospital , Beijing, China .
Nan-kuei Chen1 Brain Imaging and Analysis Center, Duke University Medical Center , Durham, North Carolina.
Feng Feng3 Department of Radiology, Peking Union Medical College Hospital , Beijing, China .
Peking Union Medical College Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNDuke Medical Center · USDuke University Hospital · US

Funding

Imaging of Intrinsic Connectivity NetworksR01NS074045 · NINDS · DUKE UNIVERSITY · PI CHEN, NAN-KUEI · 2011 to 2015
$1.5M
NINDS NIH HHS R01 NS074045NINDS NIH HHS R01-NS074045
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that has been used to treat neurological and psychiatric conditions. Although results of rTMS intervention are promising, so far, little is known about the rTMS effect on brain functional networks in clinical populations. In this study, we used a whole-brain connectivity analysis of resting-state functional magnetic resonance imaging data to uncover changes in functional connectivity following rTMS intervention and their association with motor symptoms in patients with multiple system atrophy (MSA). Patients were randomized to active rTMS or sham rTMS groups and completed a 10-session 5-Hz rTMS treatment over the left primary motor area. The results showed significant rTMS-related changes in motor symptoms and functional connectivity. Specifically, (1) significant improvement of motor symptoms was observed in the active rTMS group, but not in the sham rTMS group; and (2) several functional links involving the default mode, cerebellar, and limbic networks exhibited positive changes in functional connectivity in the active rTMS group. Moreover, the positive changes in functional connectivity were associated with improvement in motor symptoms for the active rTMS group. The present findings suggest that rTMS may improve motor symptoms by modulating functional links connecting to the default mode, cerebellar, and limbic networks, inferring a future therapeutic candidate for patients with MSA.

Indexed as

Magnetic Resonance ImagingTranscranial Magnetic StimulationAdultAgedBrainBrain MappingFemaleHumansMaleMiddle AgedMultiple System AtrophyNerve NetNeural Pathwayscerebellar networkdefault mode networklimbic networkMonte-Carlo simulationmultiple system atrophyrepetitive transcranial magnetic stimulationresting-state functional connectivityUnified Multiple System Atrophy Rating Scale

Identifiers

PMID25786196
PMCPMC4575511
OpenAlexW2003201071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.