ArticlePLoS genetics2015
Examining the evolution of the regulatory circuit controlling secondary metabolism and development in the fungal genus Aspergillus.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
- The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.Annual review of cell and developmental biology · 2026Review
- Telomere-to-Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distribution and shared evolutionary history of the Fumonisin and AAL toxin biosynthetic gene clusters.BMC genomics · 2026Article
- Plant recognition by Trichoderma Harzianum elicits upregulation of a novel secondary metabolite cluster required for colonization.Scientific reports · 2026Article
- Evolutionary origin and population diversity of a cryptic hybrid pathogen.Nature communications · 2024Article
- Evolutionary origin, population diversity, and diagnostics for a cryptic hybrid pathogen.bioRxiv : the preprint server for biology · 2023Article
- Computer-aided, resistance gene-guided genome mining for proteasome and HMG-CoA reductase inhibitors.Journal of industrial microbiology & biotechnology · 2023Article
- Comparative Transcriptomics Profiling of Perennial Ryegrass Infected with Wild Type or a ΔJournal of fungi (Basel, Switzerland) · 2023Article
- Verticillium dahliae Vta3 promotes ELV1 virulence factor gene expression in xylem sap, but tames Mtf1-mediated late stages of fungus-plant interactions and microsclerotia formation.PLoS pathogens · 2023Article
- Homeobox transcription factor HbxA influences expression of over one thousand genes in the model fungus Aspergillus nidulans.PloS one · 2023Article
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- Genome-wide association mapping reveals genes underlying population-level metabolome diversity in a fungal crop pathogen.BMC biology · 2022Article
- How to Completely Squeeze a Fungus-Advanced Genome Mining Tools for Novel Bioactive Substances.Pharmaceutics · 2022Review
- An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function.Science advances · 2022Article
- First report on the metabolic characterization of Sterigmatocystin production by selectFrontiers in microbiology · 2022Article
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- Transcription Factors in the FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes inFrontiers in fungal biology · 2021Article
- Genome-Wide Analysis of Biosynthetic Gene Cluster Reveals Correlated Gene Loss with Absence of Usnic Acid in Lichen-Forming Fungi.Genome biology and evolution · 2020Article
- Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence AcrossGenetics · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Filamentous fungi produce diverse secondary metabolites (SMs) essential to their ecology and adaptation. Although each SM is typically produced by only a handful of species, global SM production is governed by widely conserved transcriptional regulators in conjunction with other cellular processes, such as development. We examined the interplay between the taxonomic narrowness of SM distribution and the broad conservation of global regulation of SM and development in Aspergillus, a diverse fungal genus whose members produce well-known SMs such as penicillin and gliotoxin. Evolutionary analysis of the 2,124 genes comprising the 262 SM pathways in four Aspergillus species showed that most SM pathways were species-specific, that the number of SM gene orthologs was significantly lower than that of orthologs in primary metabolism, and that the few conserved SM orthologs typically belonged to non-homologous SM pathways. RNA sequencing of two master transcriptional regulators of SM and development, veA and mtfA, showed that the effects of deletion of each gene, especially veA, on SM pathway regulation were similar in A. fumigatus and A. nidulans, even though the underlying genes and pathways regulated in each species differed. In contrast, examination of the role of these two regulators in development, where 94% of the underlying genes are conserved in both species showed that whereas the role of veA is conserved, mtfA regulates development in the homothallic A. nidulans but not in the heterothallic A. fumigatus. Thus, the regulation of these highly conserved developmental genes is divergent, whereas-despite minimal conservation of target genes and pathways-the global regulation of SM production is largely conserved. We suggest that the evolution of the transcriptional regulation of secondary metabolism in Aspergillus represents a novel type of regulatory circuit rewiring and hypothesize that it has been largely driven by the dramatic turnover of the target genes involved in the process.
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