Evidence map›Paper›PMID 25785948›Full record

ArticleThe Journal of investigative dermatology2015

Hsp90 inhibitor can inhibit UV carcinogenesis.

Santosh K Katiyar

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Santosh K KatiyarDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Dermatology, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA. Electronic address: skatiyar@uab.edu.
University of Alabama at Birmingham · US

Funding

Prevention of UV-carcinogenesis through DNA repair-dependent immunomodulationR01CA140197 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KATIYAR, SANTOSH KUMAR, XU, HUI · 2010 to 2014
$1.4M
Epigenetic modulation by green tea in prevention of photocarcinogenesisR21CA140832 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KATIYAR, SANTOSH KUMAR · 2010 to 2011
$346k
Prevention of photocarcinogenesis by dietary immunomodulationI01BX001410 · VA · BIRMINGHAM VA MEDICAL CENTER · PI KATIYAR, SANTOSH KUMAR · 2012 to 2015
–
BLRD VA I01 BX001410NCI NIH HHS CA140197NCI NIH HHS CA140832NCI NIH HHS R01 CA140197NCI NIH HHS R21 CA140832
6 · The paper itself

Abstract

Extensive exposure to solar UVR is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of the skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCCs) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced (i) hyperplastic response, (ii) Hsp90β-PKCɛ interaction, and (iii) pStat3 and pAkt expression in mouse skin.

Indexed as

AnimalsBenzoquinonesCutaneous Malignant MelanomaHSP90 Heat-Shock ProteinsHumansLactams, MacrocyclicMelanomaNeoplasms, Radiation-InducedSkin NeoplasmsBenzoquinonesHSP90 Heat-Shock ProteinsLactams, Macrocyclictanespimycin

Identifiers

PMID25785948
PMCPMC4367190
OpenAlexW2073176769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.