ArticlePloS one2015
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Association between IL-6 and prognosis of gastric cancer: a retrospective study.Therapeutic advances in gastroenterology · 2023Article
- Protective effects of extracts fromFrontiers in pharmacology · 2023Article
- A proximity labeling method for protein-protein interactions on cell membrane.Chemical science · 2022Article
- Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.iScience · 2021Article
- Screening of anti-chronic nonbacterial prostatitis activity of different extractions of the aerial part ofBiomedical reports · 2021Article
- A Network Pharmacology Study Based on the Mechanism of Citri Reticulatae Pericarpium-Pinelliae Rhizoma in the Treatment of Gastric Cancer.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer.Medical oncology (Northwood, London, England) · 2020Article
- Intervenolin suppresses gastric cancer cell growth through the induction of TSP-1 secretion from fibroblast-like stromal cells.Oncology letters · 2018Article
- Differentially localized survivin and STAT3 as markers of gastric cancer progression: Association with Helicobacter pylori.Cancer reports (Hoboken, N.J.) · 2018Observational
- A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.Scientific reports · 2017Article
- Transcriptomic analysis of stromal cells from patients with endometrial carcinoma.International journal of clinical and experimental pathology · 2017Article
- Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGEScientific reports · 2016Article
- Eighth Korea-Japan Chemical Biology symposium: chemical biology notes from a small island.The Journal of antibiotics · 2016Article
- Small molecules modulating tumor-stromal cell interactions: new candidates for anti-tumor drugs.The Journal of antibiotics · 2016Review
- Modulation of Cytokines Production by Indomethacin Acute Dose during the Evolution of Ehrlich Ascites Tumor in Mice.Mediators of inflammation · 2015Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified critical stromal factors that modulate cancer growth positively and negatively. Using a cell co-culture system, we found that gastric stromal cells secreted IL-6 as a growth and survival factor for gastric cancer cells. Moreover, gastric cancer cells secreted PGE2 and TNFα that stimulated IL-6 secretion by the stromal cells. Furthermore, we found that stromal cells secreted glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Extracellular GAPDH, or its N-terminal domain, inhibited gastric cancer cell growth, a finding confirmed in other cell systems. GAPDH bound to E-cadherin and downregulated the mTOR-p70S6 kinase pathway. These results demonstrate that stromal cells could regulate cancer cell growth through the balance of these secreted factors. We propose that negative regulation of cancer growth using GAPDH could be a new anti-cancer strategy.
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