ArticlePloS one2015
Octopamine regulates antennal sensory neurons via daytime-dependent changes in cAMP and IP3 levels in the hawkmoth Manduca sexta.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 44 citations in OpenAlex.
- Hawkmoth Pheromone Transduction Involves G-Protein-Dependent Phospholipase Cβ Signaling.eNeuro · 2025Article
- Rhythms in insect olfactory systems: underlying mechanisms and outstanding questions.The Journal of experimental biology · 2024Review
- Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target.Nature communications · 2023Article
- Elucidating the molecular mechanisms of essential oils' insecticidal action using a novel cheminformatics protocol.Scientific reports · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Contribution of membrane-associated oscillators to biological timing at different timescales.Frontiers in physiology · 2023Article
- The auditory efferent system in mosquitoes.Frontiers in cell and developmental biology · 2023Review
- Knockdown of a β-Adrenergic-Like Octopamine Receptor Affects Locomotion and Reproduction ofInternational journal of molecular sciences · 2021Article
- G protein-coupled receptors as candidates for modulation and activation of the chemical senses in decapod crustaceans.PloS one · 2021Article
- Article
- Octopaminergic innervation and a neurohaemal release site in the antennal heart of the locust Schistocerca gregaria.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- The Two Main Olfactory Receptor Families inFrontiers in cellular neuroscience · 2018Review
- The Diacylglycerol Analogs OAG and DOG Differentially Affect Primary Events of Pheromone Transduction in the HawkmothFrontiers in cellular neuroscience · 2018Article
- Comparative system identification of flower tracking performance in three hawkmoth species reveals adaptations for dim light vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Article
- Releasing stimuli and aggression in crickets: octopamine promotes escalation and maintenance but not initiation.Frontiers in behavioral neuroscience · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biogenic amine octopamine (OA) mediates reward signals in olfactory learning and memory as well as circadian rhythms of sleep and activity. In the crepuscular hawkmoth Manduca sexta, OA changed pheromone detection thresholds daytime-dependently, suggesting that OA confers circadian control of olfactory transduction. Thus, with enzyme-linked immunosorbent assays we searched hawkmoth antennae for daytime-dependent changes in the concentration of OA and its respective second messengers. Antennal stimulation with OA raised cAMP- and IP3 levels. Furthermore, antennae expressed daytime-dependent changes in the concentration of OA, with maxima at Zeitgebertime (ZT) 20 when moths were active and also maximal concentrations of cAMP occurred. Maximal IP3 levels at ZT 18 and 23 correlated with maximal flight activity of male moths, while minimal IP3 levels at dusk correlated with peaks of feeding activity. Half maximal effective concentration (EC50) for activation of the OA-receptor decreased during the moth's activity phase suggesting daytime-dependent changes in OA receptor sensitivity. With an antiserum against tyramine, the precursor of OA, two centrifugal neurons were detected projecting out into the sensory cell layer of the antenna, possibly mediating more rapid stimulus-dependent OA actions. Indeed, in fast kinetic assays OA receptor stimulation increased cAMP concentrations within 50 msec. Thus, we hypothesize that fast, stimulus-dependent centrifugal control of OA-release in the antenna occurs. Additional slow systemic OA actions might be based upon circadian release of OA into the hemolymph mediating circadian rhythms of antennal second messenger levels. The resulting rhythms of odor sensitivity are suggested to underlie circadian rhythms in odor-mediated behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.