SynthesisPLoS genetics2015
A meta-analysis of gene expression signatures of blood pressure and hypertension.
Registry-linked trialOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03225183 (An RNA Sequencing Study in the Framingham Heart Study Third Generation Cohort Exam 2), which is not on this map. Cited by 80 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 3 pooled it
13.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An RNA Sequencing Study in the Framingham Heart Study Third Generation Cohort Exam 2
Who cites it
80 citing papers in PubMed, 3 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- The role of DNA methylation and histone modifications in blood pressure: a systematic review.Journal of human hypertension · 2019Pooled it
- Genome-Wide Meta-Analysis of Blood Pressure Response to βJournal of the American Heart Association · 2019Pooled it
- Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons.Physiological genomics · 2016Pooled it
- Sheep erythrocyte potassium locus highlights MYADM family regulation of electroneutral potassium chloride cotransporters (KCC).BMC genomics · 2026Article
- From Ion Channels to Blood Pressure: Genetic Disorders of Renal Tubular Transport.Electrolyte & blood pressure : E & BP · 2026Review
- Innate immune profiling reveals a specific reduction of CD57Frontiers in immunology · 2026Article
- Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.Journal of the American Heart Association · 2025Article
- Epigenomics and transcriptomics association study of blood pressure and incident diagnosis of hypertension in twins.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Pathway level metabolomics analysis identifies carbon metabolism as a key factor of incident hypertension in the Estonian Biobank.Scientific reports · 2025Article
- Precision cardiovascular medicine: shifting the innovation paradigm.Frontiers in science · 2025Article
- Treating Cardiovascular Disorders with Personalized Medicine.Cardiovascular & hematological disorders drug targets · 2025Review
- S100A10 knockdown exacerbates phenylephrine-induced cardiomyocyte hypertrophy via modulating mitochondrial oxidative phosphorylation.Frontiers in genetics · 2025Article
- Identification of metabolites from the gut microbiota in hypertension via network pharmacology and molecular docking.Bioresources and bioprocessing · 2024Article
- Enhancing selection of alcohol consumption-associated genes by random forest.The British journal of nutrition · 2024Article
- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data.BMC medical informatics and decision making · 2024Article
- Undiagnosed Pediatric Elevated Blood Pressure Is Characterized by Induction of Proinflammatory and Cytotoxic Mediators.Hypertension (Dallas, Tex. : 1979) · 2023Article
- The MAL Family of Proteins: Normal Function, Expression in Cancer, and Potential Use as Cancer Biomarkers.Cancers · 2023Review
- Decoding the mechanism of hypertension through multiomics profiling.Journal of human hypertension · 2023Review
- Influence of Butyrate on Impaired Gene Expression in Colon from Patients with High Blood Pressure.International journal of molecular sciences · 2023Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 17 institutions in 6 countries.
Tianxiao HuanThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
Marjolein J PetersDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands; Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden and Rotterdam, The Netherlands.
Luke C PillingEpidemiology and Public Health Group, Medical School, University of Exeter, Exeter, United Kingdom.
Katharina SchrammInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, München, Germany.
Claudia SchurmannDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; The Charles Bronfman Institute for Personalized Medicine, Genetics of Obesity & Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Brian H ChenThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Chunyu LiuThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Roby JoehanesThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America; Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; Hebrew SeniorLife, Boston, Boston, Massachusetts, United States of America.
Andrew D JohnsonThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; Cardiovascular Epidemiology and Human Genomics Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America.
Chen YaoThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Sai-Xia YingMathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, United States of America.
Paul CourchesneThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Nalini RaghavachariDivision of Geriatrics and Clinical Gerontology National Institute on Aging, Bethesda, Maryland, United States of America.
Richard WangGenomics Core facility Genetics & Developmental Biology Center, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Poching LiuGenomics Core facility Genetics & Developmental Biology Center, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Eva ReinmaaEstonian Genome Center, University of Tartu, Tartu, Estonia.
Abbas DehghanNetherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden and Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
Albert HofmanNetherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden and Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands; Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden and Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
Andrew SingletonLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America.
David MelzerEpidemiology and Public Health Group, Medical School, University of Exeter, Exeter, United Kingdom.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Maren CarstensenInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD e.V.), Partner Munich, Munich, Germany.
Christian HerderInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, München, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD e.V.), Partner Munich, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Michael RodenInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Marcus DörrUniversity Medicine Greifswald, Department of Internal Medicine B-Cardiology, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Stephan B FelixUniversity Medicine Greifswald, Department of Internal Medicine B-Cardiology, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Tanja ZellerUniversitäres Herzzentrum Hamburg, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
International Consortium for Blood Pressure GWAS (ICBP)
Ramachandran VasanThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America.
Christopher J O'DonnellThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Peter J MunsonMathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, United States of America.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States of America.
Holger ProkischInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, München, Germany.
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands; Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden and Rotterdam, The Netherlands.
Luigi FerrucciIntramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Daniel LevyThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
National Heart Lung and Blood Institute · USFramingham Heart Study · USHelmholtz Zentrum München · DEUniversitätsmedizin Greifswald · DEUniversity of Tartu · EEDeutsches Diabetes-Zentrum e.V. · DEErasmus University Rotterdam · NLNational Institutes of Health · USNational Institute on Aging · USNetherlands Consortium for Healthy Ageing · NLUniversity of Exeter · GBAzienda Sanitaria di Firenze · ITCenter for Information Technology · USGerman Center for Diabetes Research · DEGerman Centre for Cardiovascular Research · DEHeinrich Heine University Düsseldorf · DEUniversity of California, Los Angeles · US
Funding
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MGenomic Epidemiology of Cardiovascular DiseaseZIAHL006002 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI O'DONNELL, CHRISTOPHER · 2009 to 2015
$8.0MStatistical And Computational Methods For Gene Expression and Proteomic AnalysisZIACT000266 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI MUNSON, PETER J · 2009 to 2016
$4.2MGene Expression for Functional Genomics in Human PopulationsZIAHL006175 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI O'DONNELL, CHRISTOPHER · 2013 to 2015
$2.2MFunctional Genetic Variation Underlying Cardiovascular Genomic EpidemiologyZIAHL006173 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI O'DONNELL, CHRISTOPHER · 2013 to 2015
$2.0MTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01-HC-25195Wellcome TrustWellcome Trust WT097835MF
Abstract
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%-9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension.
Indexed as
Genome-Wide Association StudyBlood PressureGene Expression RegulationGenetic Predisposition to DiseaseGenotypeHumansHypertensionPolymorphism, Single NucleotideTranscriptome
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Read underepoch 390
Registered trials
NCT03225183ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.