ArticleToxins2015
Isolation and preliminary characterization of proteinaceous toxins with insecticidal and antibacterial activities from black widow spider (L. tredecimguttatus) eggs.
Article in Toxins, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Animal Venom Pharmacological Resources: Exploiting Bioactive Peptides to Target Multi-Drug-Resistant Bacteria.Biochemistry research international · 2026Review
- The apple of discord: can spider cocoons be equipped with antimicrobial factors?-a systematic review.Frontiers in zoology · 2025Review
- Venom gland organogenesis in the common house spider.Scientific reports · 2024Article
- Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications.Molecules (Basel, Switzerland) · 2023Review
- Insights into the mediation of CaJournal of cell communication and signaling · 2023Article
- Analysis of differentially expressed genes discovers Latroeggtoxin VI-induced changes and SYNJ1 as a main target in PC12 cells.BMC genomics · 2023Article
- Widow spiders in the New World: a review onThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Partial proteomic analysis of brown widow spider (Toxicon: X · 2020Article
- Eggshell spheres protect brown widow spider ( Latrodectus geometricus) eggs from bacterial infection.Journal of the Royal Society, Interface · 2019Article
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- Anticancer, antimicrobial, and analgesic activities of spider venoms.Toxicology research · 2018Review
- Article
- Transcriptome Analysis to Understand the Toxicity of Latrodectus tredecimguttatus Eggs.Toxins · 2016Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The eggs of black widow spider (L. tredecimguttatus) have been demonstrated to be rich in toxic proteinaceous components. The study on such active components is of theoretical and practical importance. In the present work, using a combination of multiple biochemical and biological strategies, we isolated and characterized the proteinaceous components from the aqueous extract of the black widow spider eggs. After gel filtration of the egg extract, the resulting main protein and peptide peaks were further fractionated by ion exchange chromatography and reversed-phase high performance liquid chromatography. Two proteinaceous components, named latroeggtoxin-III and latroeggtoxin-IV, respectively, were purified to homogeneity. Latroeggtoxin-III was demonstrated to have a molecular weight of about 36 kDa. Activity analysis indicated that latroeggtoxin-III exhibited neurotoxicity against cockroaches but had no obvious effect on mice, suggesting that it is an insect-specific toxin. Latroeggtoxin-IV, with a molecular weight of 3.6 kDa, was shown to be a broad-spectrum antibacterial peptide, showing inhibitory activity against all five species of bacteria tested, with the highest activity against Staphylococcus aureus. Finally, the implications of the proteinaceous toxins in egg protection and their potential applications were analyzed and discussed.
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