Evidence map›Paper›PMID 25785276›Full record

ArticleJournal of diabetes research2015

Polymorphisms of GLP-1 receptor gene and response to GLP-1 analogue in patients with poorly controlled type 2 diabetes.

Chia-Hung Lin, Yun-Shien Lee, Yu-Yao Huang, Sheng-Hwu Hsieh, Zih-Syuan Chen, Chi-Neu Tsai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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  12. Advances in multi-omics study of biomarkers of glycolipid metabolism disorder.Computational and structural biotechnology journal · 2022
    Review
  13. Pharmacogenetics of new classes of antidiabetic drugs.Bosnian journal of basic medical sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chia-Hung LinDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan ; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan.
Yun-Shien LeeDepartment of Biotechnology, Ming Chuan University, Taoyuan 333, Taiwan ; Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Yu-Yao HuangDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Sheng-Hwu HsiehDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Zih-Syuan ChenGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan.
Chi-Neu TsaiGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan.
Chang Gung Memorial Hospital · TWChang Gung University · TWMing Chuan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe relationship between genetic polymorphisms of the glucagon-like peptide-1 (GLP-1) receptor (GLP1R) gene and unresponsiveness to GLP-1 analogue treatment in patients with poorly controlled type 2 diabetes mellitus (DM) is unclear.

methodsThirty-six patients with poorly controlled type 2 DM were enrolled and they received six days of continuous subcutaneous insulin infusion for this study. After the normalization of blood glucose in the first 3 days, the patients then received a combination therapy with injections of the GLP-1 analogue, exenatide, for another 3 days. All 13 exons and intron-exon boundaries of the GLP1R gene were amplified to investigate the association.

resultsThe short tandem repeat at 8GA/7GA (rs5875654) had complete linkage disequilibrium (LD, with r2 = 1) with single nucleotide polymorphism (SNP) rs761386. Quantitative trait loci analysis of GLP1R gene variation with clinical response of GLP1 analogue showed the missense rs3765467 and rs761386 significantly associated with changes in the standard deviation of plasma glucose (SDPG(baseline) - SDPG(treatment with GLP-1 analogue)) (P = 0.041 and 0.019, resp.). The reported P values became insignificant after multiple testing adjustments.

conclusionThe variable response to the GLP-1 analogue was not statistically correlated with polymorphisms of the GLP1R gene in patients with poorly controlled type 2 DM.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2FemaleGenotypeGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucose Tolerance TestHospitalizationHumansHypoglycemiaInfusions, SubcutaneousInsulinLinkage DisequilibriumMaleMicrosatellite RepeatsMiddle AgedBlood GlucoseGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorInsulin

Identifiers

PMID25785276
PMCPMC4345081
OpenAlexW2066585468

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.