ArticleResearch in cardiovascular medicine2014
LV Dyssynchrony Assessed With Phase Analysis on Gated Myocardial Perfusion SPECT Can Predict Response to CRT in Patients With End-Stage Heart Failure.
Article in Research in cardiovascular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- A method using deep learning to discover new predictors from left-ventricular mechanical dyssynchrony for CRT response.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prediction of Cardiac Resynchronization Therapy Response Using Quantitative Gated Myocardial Perfusion Imaging.The Journal of innovations in cardiac rhythm management · 2023Article
- Mechanical dyssynchrony: How do we measure it, what it means, and what we can do about it.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Mechanisms of left ventricular dyssynchrony: A multinational SPECT study of patients with bundle branch block.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Left ventricular regional asynchrony: Earliest marker for ischemic cardiomyopathy?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Predicting left ventricular dyssynchrony: Can nuclear cardiology bring us closer "In Sync"?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Useful assessment of myocardial viability and dyssynchrony from gated perfusion scintigraphy for better qualification for resynchronization therapy. Part 3.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2020Review
- Electrical and mechanical dyssynchrony in patients with right bundle branch block.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- A troubled marriage: When electrical and mechanical dyssynchrony don't go along.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- True complete left bundle branch block reveals dyssynchrony evaluated by semiconductor single-photon emission computed tomography.Journal of arrhythmia · 2019Article
- Left-ventricular mechanical dyssynchrony in the prognosis of dilated cardiomyopathy: Which parameter is more useful?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Comparison of Gated SPECT Myocardial Perfusion Imaging with Echocardiography for the Measurement of Left Ventricular Volumes and Ejection Fraction in Patients With Severe Heart Failure.Research in cardiovascular medicine · 2016Article
- The Age of Reason for Gated SPECT MPI to Deal With Cardiac Dyssynchrony.Research in cardiovascular medicine · 2015Article
- Comparison of Left Ventricular Phase Parameters Analysis between Two Software Programs in Patients with Normal Gated Single-photon Emission Computed Tomography-Myocardial Perfusion Imaging.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac resynchronization therapy (CRT) is an established treatment in patients with end-stage heart failure and wide QRS complex. However, about 30% of patients do not benefit from CRT (non-responder). Recent studies with tissue Doppler imaging yielded disappointing results in predicting CRT responders. Phase analysis was developed to allow assessment of LV dyssynchrony by gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (GMPS).
objectivesThe aim of present study was to investigate the role of quantitative GMPS-derived LV dyssynchrony data to predict CRT responder. PATIENTS AND
methodsThirty eligible patients for CRT implantation underwent GMPS and echocardiography. Response to CRT was evaluated six months after the device implantation. Clinical response to CRT was defined as 50 meters increase in 6-minute walking test (6-MWT) distance. Echocardiographic response to CRT was defined as ≥ 15% decrease in left ventricular end-systolic volume (LVESV). The lead position was considered concordant if it was positioned at the area of latest mechanical activation, and discordant if located outside the area of latest mechanical activation.
resultsClinical response to CRT was observed in 74% of patients. However, only 57% of patients were responder according to the echo criteria. There were statistically significant differences between CRT responders and non-responders for GMPS-derived variables, including phased histogram bandwidth (PHB), phase SD (PSD), and Entropy. Moreover, a cutoff value of 112° for PHB with a sensitivity of 72% and specificity of 70%, a cutoff value of 21° for PSD with a sensitivity of 90% and specificity of 74%, and a cutoff of 52% for Entropy with a sensitivity of 90% and a specificity of 80% were considered to discriminate responders and non-responders. CRT response was more likely in patients with concordant LV lead position compared to those with discordant LV lead position.
conclusionsGMPS-derived LV dyssynchrony variables can predict response to CRT with good sensitivity and specificity.
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