ArticleInternational journal of clinical and experimental medicine2015
Molecular epidemiology of aminoglycosides resistance on Klebsiella pneumonia in a hospital in China.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Large-scale assessment of antimicrobial resistance marker databases for genetic phenotype prediction: a systematic review.The Journal of antimicrobial chemotherapy · 2020Pooled it
- Klebsiella pneumoniae in the global AMR: resistance mechanisms and genomic adaptation.World journal of microbiology & biotechnology · 2026Review
- Extended spectrum beta-lactamase and aminoglycoside modifying enzyme genes in multi drug resistant Gram-negative bacteria: A snapshot from a tertiary care centre.Medical journal, Armed Forces India · 2024Article
- Resistance to aminoglycoside and quinolone drugs amongHeliyon · 2024Article
- Antimicrobial resistance patterns ofVeterinary world · 2023Article
- Updates on the Virulence Factors Produced by Multidrug-ResistantMicroorganisms · 2023Review
- Molecular evaluation of aminoglycosides resistance and biofilm formation inHealth science reports · 2023Article
- Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing.Frontiers in cellular and infection microbiology · 2023Review
- Antibiotic Heteroresistance inInternational journal of molecular sciences · 2021Review
- Frequency ofReports of biochemistry & molecular biology · 2021Article
- Multidrug Resistance in Integron Bearing Klebsiella pneumoniae isolated from Alexandria University Hospitals, Egypt.Current microbiology · 2020Article
- The complex genetic region conferring transferable antibiotic resistance in multidrug-resistant and extremely drug-resistantNew microbes and new infections · 2020Article
- A 7-year surveillance of the drug resistance in Klebsiella pneumoniae from a primary health care center.Annals of clinical microbiology and antimicrobials · 2019Article
- Molecular Identification of Aminoglycoside-Modifying Enzymes and Plasmid-Mediated Quinolone Resistance Genes amongInternational journal of microbiology · 2017Article
- Microarray-based long oligonucleotides probe designed for Brucella Spp. detection and identification of antibiotic susceptibility pattern.Electronic physician · 2016Article
- Evaluating the Frequency ofAvicenna journal of medical biotechnologyArticle
- Pneumonia Caused by Klebsiella spp. in 46 Horses.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the molecular epidemiology of aminoglycosides resistance among Klebsiella pneumonia in hospitals in China, the antibiotics resistance and the possession of extended-spectrum β-lactamases (ESBLs) from 162 isolates were examined using Kirby-Bauer disk diffusion and PCR sequencing. Overall, 47.5% (77/162) of strains showed an ESBL phenotype. According to antibiotics resistance, ESBLs-positive K. pneumoniae showed significantly higher resistance to most antibiotics than ESBLs-negative strains (P<0.05). Moreover, 162 strains harboured aminoglycoside-modifying enzymes genes (AMEs) including aac (3)-II (n = 49), aac (6')-Ib (n = 32), ant (3")-I (n = 22) and ant (2")-I (n = 7). Overall, 11.1% (18/162) and 6.2% (10/162) of isolates carried 16S rRNA methylase genes (armA and rmtB), in which the aminoglycoside MIC was more than 256 μg/ml. In conclusion, our study characterised aminoglycosides resistance among K. pneumoniae strains in China hospitals and revealed antibiotic resistance and the increased presence of AMEs and 16S rRNA methylase genes in K. pneumonia, enabling the prevalence of aminoglycosides resistance of K. pneumoniae to be tracked from patients.
Indexed as
Identifiers
25785141PMC4358596W1482404537What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.