ArticleInternational journal of clinical and experimental medicine2015
Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 (MACC1) overexpression in colorectal cancer: a meta-analysis.Oncotarget · 2016Pooled it
- Potential Prognostic and Metastatic Implications of MACC1 and MMP8 in Colorectal Cancer.Current issues in molecular biology · 2026Article
- LncRNA FGD5-AS1 Facilitates the Radioresistance of Breast Cancer Cells by Enhancing MACC1 Expression Through Competitively Sponging miR-497-5p.Frontiers in oncology · 2021Article
- Emerging Mechanisms and Treatment Progress on Liver Metastasis of Colorectal Cancer.OncoTargets and therapy · 2021Review
- Restoring Treatment Response in Colorectal Cancer Cells by Targeting MACC1-Dependent ABCB1 Expression in Combination Therapy.Frontiers in oncology · 2020Article
- MACC1 and HGF are associated with survival in patients with gastric cancer.Oncology letters · 2018Article
- Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer.Oncology letters · 2017Article
- Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer.BMC cancer · 2016Article
- Article
- Mir-338-3p Inhibits Malignant Biological Behaviors of Glioma Cells by Targeting MACC1 Gene.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Observational
- Targeting MACC1 by RNA interference inhibits proliferation and invasion of bladder urothelial carcinoma in T24 cells.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMetastasis-associated in colon cancer-1 (MACC1), a new gene associated with primary and metastatic colon cancer, promotes tumor cell growth as well as the development of distant metastasis. The aim of this study is to investigate the expression of MACC1 protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis. MATERIALS AND
methodsExpression of MACC1 protein was detected immunohistochemically in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between MACC1 protein expression and clinicopathological parameters, postoperative liver metastasis were analyzed.
resultsImmunohistochemistry examination showed that MACC1 protein expression was significantly more abundant in colon cancer tissues than in normal colon tissues (P = 0.038), Positive rate of MACC1 expression in colon cancer tissues was increased significantly in patients with lymph node metastases (P = 0.001) and higher T stages (P = 0.006). Postoperative live metastasis-free survival period was significantly longer in negative MACC1 expression group than that of positive MACC1 expression group (36.4 ± 2.85 vs. 28.6 ± 2.02 months, P = 0.014). Multivariate analysis showed that MACC1 expression level is an independent prognostic factor for postoperative live metastasis-free survival (95% confidence interval [CI] =1.32-3.38, P = 0.006).
conclusionsOur results suggest that MACC1 expression level might play an important role in colon cancer invasion and MACC1 expression level is an independent biomarker for postoperative liver metastasis in patients with colon cancer.
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Identifiers
25785098PMC4358553What OpenQuestion holds
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