ArticleInternational journal of clinical and experimental medicine2015
Role of blood tumor markers in predicting metastasis and local recurrence after curative resection of colon cancer.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 26 citations in OpenAlex.
- Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I-III colorectal cancer: a retrospective cohort study.Updates in surgery · 2022Article
- Hypothesis to explain the disparity in the proportion of liver metastases between appendiceal and colorectal cancer.The British journal of surgery · 2022Article
- Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer.Frontiers in surgery · 2022Article
- Plasma DNA Integrity as a Prognostic Biomarker for Colorectal Cancer Chemotherapy.Journal of oncology · 2021Article
- The prognostic value of combined tumor markers and systemic immune-inflammation index in colorectal cancer patients.Langenbeck's archives of surgery · 2020Article
- Prognosis prediction model based on competing endogenous RNAs for recurrence of colon adenocarcinoma.BMC cancer · 2020Article
- Can factors that influence nodal dissemination in patients with colorectal cancer be identified? Own experience.Przeglad gastroenterologiczny · 2020Article
- The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients.PeerJ · 2020Article
- A reliable method for colorectal cancer prediction based on feature selection and support vector machine.Medical & biological engineering & computing · 2019Article
- Predictive Values of the Selected Inflammatory Indexes in Colon Cancer.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the prognostic value of carcinoembryonic antigen (CEA), CA199, CA724 and CA242 in peripheral blood and local draining venous blood in colon cancer patients after curative resection.
methods92 colon cancer patients who received curative resection were retrospectively analyzed. The CEA, CA199, CA724 and CA242 were detected in peripheral blood and local draining venous blood.
resultsMetastasis or local recurrence was found in 29 (29/92, 31.5%) patients during follow-up period. 92 patients were divided into two groups: metastasis/local recurrence group (n = 29) and non-metastasis/local recurrence group (n = 63). Peripheral venous CEA, CA199, CA724 and CA242 (p-CEA, p-CA199, p-CA724 and p-CA242) were comparable between two groups (P > 0.05). The median draining venous CEA (d-CEA) in metastases/local recurrence group (23.7 ± 6.9 ng/ml) was significantly higher than that in non-metastases/local recurrence group (18.1 ± 6.3 ng/ml; P < 0.05), but marked differences were not observed in draining venous CA199, CA724 and CA242 (d-CA199, d-CA724 and d-CA242) between two groups (P > 0.05). The optimal cut-off value of d-CEA was 2.76 ng/ml, with the sensitivity and specificity of 90% and 40% in the prediction of metastasis or local recurrence, respectively. d-CEA correlated with tumor differentiation, T stage, TNM stage, metastasis and local recurrence. Subgroup analysis showed that, of 41 patients with stage II colon cancer, the optimal cut-off value of d-CEA was 8.78 ng/mL, and the sensitivity and specificity were 87.5% and 69.7% in the prediction of metastasis or local recurrence, respectively.
conclusiond-CEA may be a prognostic factor for stage II colon cancer patients.
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Identifiers
25785084PMC4358539W190573192What OpenQuestion holds
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