Evidence map›Paper›PMID 25785047›Full record

ArticleInternational journal of clinical and experimental medicine2015

IL-1RA gene-transfected bone marrow-derived mesenchymal stem cells in APA microcapsules could alleviate rheumatoid arthritis.

Jianhua Hu, Hongjian Li, Guanhao Chi, Zhao Yang, Yi Zhao, Wei Liu, Chao Zhang

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

2.1field-weighted citation impact, top 14% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

Development of mesenchymal stem cells: therapeutic effect and prospect for rheumatoid arthritis.Stem cell research & therapy · 2025
Review
Bone marrow derived mesenchymal stem cells therapy for rheumatoid arthritis - a concise review of past ten years.Molecular biology reports · 2023
Review
Current Immunotherapy Strategies for Rheumatoid Arthritis: The Immunoengineering and Delivery Systems.Research (Washington, D.C.) · 2023
Review
Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies.EBioMedicine · 2021
Review
Multipotent Mesenchymal Stromal Cells in Rheumatoid Arthritis and Systemic Lupus Erythematosus; From a Leading Role in Pathogenesis to Potential Therapeutic Saviors?Frontiers in immunology · 2021
Review
Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications.Cells · 2020
Review
Improved therapeutic potential of MSCs by genetic modification.Gene therapy · 2018
Review
Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications.Journal of musculoskeletal & neuronal interactions · 2018
Review
Mesenchymal stem cells in the treatment of Cesarean section skin scars: study protocol for a randomized, controlled trial.Trials · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jianhua HuDepartment of Orthopedics, First People's Hospital of Yunnan Province Kunming 650032, Yunnan Province, China.

Hongjian LiDepartment of Orthopedics, First People's Hospital of Yunnan Province Kunming 650032, Yunnan Province, China.

Guanhao ChiDepartment of Orthopedics, First People's Hospital of Yunnan Province Kunming 650032, Yunnan Province, China.

Zhao YangDepartment of Orthopedics, First People's Hospital of Yunnan Province Kunming 650032, Yunnan Province, China.

Yi ZhaoDepartment of Orthopedics, First People's Hospital of Yunnan Province Kunming 650032, Yunnan Province, China.

Wei LiuDepartment of Orthopedics, First People's Hospital of Yunnan Province Kunming 650032, Yunnan Province, China.

Chao ZhangDepartment of Orthopedics, First People's Hospital of Yunnan Province Kunming 650032, Yunnan Province, China.

First People's Hospital of Yunnan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn order to investigate the encapsulation of interleukin 1 receptor antagonist (IL-RA) gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of interleukin 1 receptor antagonist (IL-RA) to treat Rheumatoid arthritis (RA).

methodsWe transfect mesenchymal stem cells with IL-RA gene, and quantify the IL-RA proteins released from the encapsulated cells followed by microencapsulation of recombinant mesenchymal stem cells, and thus observe the permeability of APA microcapsules and evaluate clinical effects after induction and treatment of collagen-induced arthritis (CIA). The concentration of IL-RA in the supernatant was determined by IL-RA ELISA kit by run in technical triplicates using samples from three separate mice.

resultsEncapsulated IL-RA gene-transfected cells were capable of constitutive delivery of IL-RA proteins for at least 30 days. Moreover, the APA microcapsules could inhibit the permeation of fluorescein isothiocyanate-conjuncted immunoglobulin G. Also, it has been found that the APA microcapsules can significantly attenuate collagen induced arthritis after delivering of APA microcapsules to rats.

conclusionsOur results demonstrated that the nonautologous IL-RA gene-transfected stem cells are of potential utility for RA therapy.

Indexed as

alginate-poly-L-lysine microcapsulesencapsulationIL-RA gene-modified mesenchymal stem cellspersistent deliveryRheumatoid arthritis

Identifiers

PMID25785047

PMCPMC4358502

OpenAlexW315593768

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.