ArticleInternational journal of clinical and experimental medicine2015
Effect of Chuanminshen violaceum polysaccharides and its sulfated derivatives on immunosuppression induced by cyclophosphamide in mice.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Hematopoietic effects of Fufang E'jiao Jiang revealed by microbiome, metabolome and transcriptome analyses: a multi-omics strategy.Frontiers in immunology · 2025Article
- Calcitriol reduces Newcastle disease virus replication by modulating galectin 3 and pro-inflammatory cytokines.Archives of virology · 2024Article
- Polysaccharide from aerial part ofFrontiers in immunology · 2023Article
- Tannins extract from Galla Chinensis can protect mice from infection by Enterotoxigenic Escherichia coli O101.BMC complementary medicine and therapies · 2021Article
- Immunomodulatory effect of Acanthopanax senticosus polysaccharide on immunosuppressed chickens.Poultry science · 2021Article
- The polysaccharide ofRSC advances · 2018Article
- Optimization and evaluation of astragalus polysaccharide injectable thermoresponsive in-situ gels.PloS one · 2017Article
- Effect of ModifiedEvidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One hundred mice were randomly divided into five groups. The mice in one group were injected with physiological saline as the normal control group. The mice in the other four groups were injected with physiological saline, sulfated Chuanminshen violaceum polysaccharides (SCVP), Chuanminshen violaceum polysaccharide (CVP) and astragalus polysaccharide (AP) once daily for 7 d and then with cyclophosphamide (CY) in the last 3 d. The serum cytokine level, apoptosis protein expressions, spleen lymphocyte proliferation, changes in peripheral blood T-cell subsets, and immune organ index were then measured. Results showed that SCVP and CVP can overcome CY-induced immunosuppression by promoting spleen lymphocyte proliferation, raising serum IFN-γ and IL-2 levels, enlarging immune organ indexes, and decreasing excessive apoptosis. Moreover, SCVP and CVP showed the potential to treat autoimmune diseases based on CD4(+)/CD8(+) ratios. Results suggested that SCVP and CVP exhibited the potential to treat autoimmune and immunosuppression diseases.
Indexed as
Identifiers
25785030PMC4358485W316734303What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.