ArticleInternational journal of clinical and experimental medicine2015
Alpha-lipoic acid attenuates trinitrobenzene sulfonic acid-induced ulcerative colitis in mice.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Therapeutic potential of alpha-lipoic acid on mitochondrial dynamics, oxidative/nitrosative stress, and histopathological changes in rat ulcerative colitis model.Inflammopharmacology · 2025Article
- Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis.Experimental and therapeutic medicine · 2024Article
- Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis.Molecular and cellular biochemistry · 2024Article
- Nanotechnology-driven improvisation of red algae-derived carrageenan for industrial and bio-medical applications.World journal of microbiology & biotechnology · 2023Review
- Interplay of Biochemical, Genetic, and Immunohistochemical Factors in the Etio-Pathogenesis of Gastric Ulcer in Rats: A Comparative Study of the Effect of Pomegranate Loaded Nanoparticles Versus Pomegranate Peel Extract.Frontiers in physiology · 2021Article
- Functional characterization of CXCR4 in mediating the expression of protein C system in experimental ulcerative colitis.American journal of translational research · 2017Article
- Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways.Scientific reports · 2016Article
- Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model.PloS one · 2016Article
- Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis.Frontiers in pharmacology · 2016Article
- Creative arts program as an intervention for PTSD: a randomized clinical trial with motor vehicle accident survivors.International journal of clinical and experimental medicine · 2015Article
- The therapeutic benefits of epigallocatechin gallate in rats with experimentally induced ulcerative colitis are achieved by influencing inflammation and apoptosis.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcerative colitis (UC), characterized by inflammation, oxidative stress, and increased intestinal epithelial cell apoptosis, is an immunologically mediated chronic intestinal disorder. The present study was aimed at investigating the protective effects of alpha-lipoic acid (ALA) against trinitrobenzene sulfonic acid (TNBS)-induced UC and the underlying mechanism. ALA of 80 mg/kg bw/day was administered by gastric gavage to mice for 7 days after TNBS-induced UC. Our data indicated that ALA effectively facilitated recovery of pathologic changes in the colon, as evidenced by a significant increase of body weight, decrease of colon mass index and histopathological score. Furthermore, ALA significantly inhibited TNBS-induced apoptosis, which partly due to up-regulation of Bcl-2 expression, reduction of Bax expression and caspase-3, caspase-9 activity. ALA reduced malondialdehyde (MDA), nitric oxide (NO), and inducible nitric oxide synthase (iNOS) levels, and restored superoxide dismutase (SOD) activity and glutathione (GSH) content in colon tissues from TNBS-challenged mice. Additionally, phosphorylation of extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 kinase (p38) in colon tissues were significantly inhibited by ALA treatment. In summary, we demonstrate that ALA has protective properties against TNBS-induced UC through anti-apoptosis, anti-oxidant actions, and mitogen-activated protein kinase (MAPK) signaling pathway. Our present findings suggest a therapeutic potential of ALA in UC.
Indexed as
Identifiers
25785006PMC4358461W2290743965What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.