Evidence map›Paper›PMID 25785003›Full record

ArticleInternational journal of clinical and experimental medicine2015

Association between nonalcoholic fatty liver disease and colorectal adenoma: a systematic review and meta-analysis.

Wenjin Ding, Jiangao Fan, Jianjun Qin

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  11. United European gastroenterology journal · 2020
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  14. Review
  15. Article
  16. Comorbidities and Nonalcoholic Fatty Liver Disease: The Chicken, the Egg, or Both?Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019
    Article
  17. Observational
  18. [Guidelines of prevention and treatment for nonalcoholic fatty liver disease: a 2018 update].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
  19. [Research on the natural history of non-alcoholic fatty liver disease should be taken seriously].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Wenjin DingDepartment of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Jiangao FanDepartment of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Jianjun QinShanghai Institute of Disaster Prevention and Relief, Tongji University Shanghai, China.
Shanghai Institute of Disaster Prevention and Relief · CNShanghai Jiao Tong University · CNXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSeveral existing studies indicated that nonalcoholic fatty liver disease (NAFLD) may be associated with colorectal adenoma, but the results and risk factors are controversial. A systematic review of studies was conducted to explore these issues by meta-analysis.

methodsWe searched the Pubmed, Embase, Cochrane library, Medline and Web of Science databases for studies published before May 30(th), 2014. A statistical analysis was performed using RevMan 5.2 software.

resultsSeven studies involving 11,905 participants from different regions were included. Among them, five trials carried out subgroup of NAFLD patients in colorectal adenoma population. The result showed NAFLD was significantly correlated with adenoma of colon (Odds ratio [OR] = 1.56, 95% confidence interval [CI]: 1.22-1.99, P = 0.0003). It could be found in stratified analysis that patients had more chance to get multiple adenomas when they suffered NAFLD (Rate ratio [RR]: 1.52, 95% CI: 1.08-2.13, P = 0.02). Such risk factors of NAFLD as age, waist circumference, body mass index (BMI), disorder of lipid metabolism, hyperglycemia and high blood pressure (HBP) increased risk of colorectal adenoma (Age: mean difference [MD]: 2.81, 95% CI: 0.33-5.28; Waist: MD: 2.84, 95% CI: 2.14-3.54; BMI: MD: 0.85, 95% CI: 0.69-1.01; High-density lipoprotein: MD: -2.46, 95% CI: -3.68 to -1.24; Triglyceride: MD: 16.12, 95% CI: 8.89-23.36; Low-density lipoprotein: MD: 6.04, 95% CI: 3.60-8.48; Cholesterol: MD: 4.25, 95% CI: 0.87-7.63; Fasting glucose: MD: 2.27, 95% CI: 1.24-3.30; HBP: OR = 1.51, 95% CI: 1.22-1.88), while diabetes had no significant association with it (OR = 1.43, 95% CI: 0.94-2.17, P = 0.09). Besides, NAFLD didn't affect the location, size and advanced type of colorectal adenoma (P > 0.05).

conclusionThe present systematic review and meta-analysis demonstrated NAFLD was closely associated with great risk of colorectal adenoma and its number, but not with its location, size and advanced type. Waist, obesity, lipid profiles, glucose, hypertension played roles in the process of colorectal adenoma.

Indexed as

colorectal adenomameta-analysisNonalcoholic fatty liver diseaserisk factors

Identifiers

PMID25785003
PMCPMC4358458
OpenAlexW2341733991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.