ArticleInternational journal of clinical and experimental medicine2015
AMPK is required for PM2.5-induced autophagy in human lung epithelial A549 cells.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Effects of air pollutants on the incidence, progression, and mortality of idiopathic pulmonary fibrosis: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- [Epidemiological characteristics of respiratory syncytial virus infection in children in Nanchang and its correlation with climate environmental factors].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Assessing the risk of consuming fish from Kanyakumari (Tamil Nadu), India: An evaluative study on bioaccumulated heavy metals in different fish species using inductively coupled plasma mass spectrometry.Toxicology reports · 2024Article
- Cell Death Pathways: The Variable Mechanisms Underlying Fine Particulate Matter-Induced Cytotoxicity.ACS nanoscience Au · 2023Review
- Study on Lung Injury Caused by Fine Particulate Matter and Intervention Effect ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- PM2.5-related cell death patterns.International journal of medical sciences · 2021Review
- Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.Cell death & disease · 2020Article
- Construction of polluted aerosol in accumulation that affects the incidence of lung cancer.Heliyon · 2020Article
- Xiaoqinglong Decoction Protects the Lungs of AECOPD Mice through the AMPK/mTOR Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Metformin protects against PMRedox biology · 2020Article
- Pulmonary inflammation induced by low-dose particulate matter exposure in mice.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- In Vitro and In Vivo Experimental Studies of PMInternational journal of environmental research and public health · 2018Review
- Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases.Oncology letters · 2018Review
- Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial.Experimental and therapeutic medicine · 2017Article
- PM2.5 exposure decreases viability, migration and angiogenesis in human umbilical vein endothelial cells and human microvascular endothelial cells.Molecular medicine reports · 2017Article
- Autophagy Induced FHL2 Upregulation Promotes IL-6 Production by Activating the NF-κB Pathway in Mouse Aortic Endothelial Cells after Exposure to PM2.5.International journal of molecular sciences · 2017Article
- Sirtuin 1 and aging theory for chronic obstructive pulmonary disease.Analytical cellular pathology (Amsterdam) · 2015Review
- PM2.5 activated NLRP3 inflammasome and IL-1β release in MH-S cells by facilitating autophagy via activating Wnt5a.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim is to investigate the molecular mechanisms underlying the PM2.5-induced autophagy in human lung cancer epithelial cells (A549). The effects of the PM2.5 on morphological and biochemical markers of autophagy in A549 were analyzed by electron microscopy, GFP-LC3 puncta was observed by confocal fluorescence microscope. The effects of phosphorylation of AMPK, mTOR, AKT, ERK, JNK, and p53 on LC3II in A549 were observed following PM2.5 exposure; the role of autophagy in PM2.5-induced apoptosis was examined using 3-methyladenine and rapamycin. PM2.5 induced morphological and biochemical markers of autophagy in A549. Phosphorylation of AMPK and dephosphorylation of mTOR were observed following PM2.5 treatment, and AMPK inhibitor blocked LC3B-II expression. In addition, we demonstrated that PM2.5-induced autophagy confers a pro-survival role in host defense.
Indexed as
Identifiers
25784975PMC4358430W19905814What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.