Evidence map›Paper›PMID 25784952›Full record

ArticleImmunity & ageing : I & A2015

Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment.

Mina Elahy, Connie Jackaman, John Cl Mamo, Virginie Lam, Satvinder S Dhaliwal, Corey Giles, Delia Nelson, Ryusuke Takechi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & ageing : I & A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 1 synthesis or guideline pooled it, 297 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mina ElahyCHIRI Institute for Ageing and Chronic Disease, Curtin University, Bentley, 6102 WA Australia ; School of Public Health, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
Connie JackamanCHIRI Institute for Ageing and Chronic Disease, Curtin University, Bentley, 6102 WA Australia ; School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
John Cl MamoCHIRI Institute for Ageing and Chronic Disease, Curtin University, Bentley, 6102 WA Australia ; School of Public Health, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
Virginie LamCHIRI Institute for Ageing and Chronic Disease, Curtin University, Bentley, 6102 WA Australia ; School of Public Health, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
Satvinder S DhaliwalSchool of Public Health, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
Corey GilesCHIRI Institute for Ageing and Chronic Disease, Curtin University, Bentley, 6102 WA Australia ; School of Public Health, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
Delia NelsonCHIRI Institute for Ageing and Chronic Disease, Curtin University, Bentley, 6102 WA Australia ; School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
Ryusuke TakechiCHIRI Institute for Ageing and Chronic Disease, Curtin University, Bentley, 6102 WA Australia ; School of Public Health, Faculty of Health Sciences, Curtin University, Bentley, 6102 WA Australia.
Curtin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFunctional loss of blood-brain barrier (BBB) is suggested to be pivotal to pathogenesis and pathology of vascular-based neurodegenerative disorders such as Alzheimer's disease. We recently reported in wild-type mice maintained on standard diets, progressive deterioration of capillary function with aging concomitant with heightened neuroinflammation. However, the mice used in this study were relatively young (12 months of age) and potential mechanisms for loss of capillary integrity were not investigated per se. The current study therefore extended the previous finding to investigate the effect of aging on BBB integrity in aged mice at 24 months and its potential underlying molecular mechanisms.

resultsImmunomicroscopy analyses confirmed significantly increased capillary permeability with heightened neuroinflammation in naturally aged 24-month old mice compared to young control at 3 months of age. Aged mice showed significant attenuation in the expression of BBB tight junction proteins, occludin-1 and to lesser extent ZO-1 compared to young mice. In addition, TNF-α in cerebral endothelial cells of aged mice was significantly elevated compared to controls and this was associated with heightened peripheral inflammation. The expression of ICAM-1 and VCAM-1 remained unelevated, and no sign of leukocyte recruitment was observed in aged mice.

conclusionThe BBB breakdown that occurs during ordinary aging is associated with inflammation and disruption of tight junction complex assembly but not through leukocyte trafficking.

Indexed as

AgingBlood–brain barrierInflammationLeukocyte infiltrationNeurodegenerative disorderNeuroinflammationTight junction complex

Identifiers

PMID25784952
PMCPMC4362825
OpenAlexW2099448948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.