ArticleFrontiers in genetics2015
Pharmacological classes that extend lifespan of Caenorhabditis elegans.
Article in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed.
- Geroprotective effects of bioactive compounds against hydroquinone toxicity in Drosophila melanogaster: an in vivo and in silico insight.Biogerontology · 2026Article
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- Uncovering the Molecular Pathways Implicated in the Anti-Cancer Activity of the Imidazoquinoxaline Derivative EAPB02303 Using aInternational journal of molecular sciences · 2024Article
- Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology.bioRxiv : the preprint server for biology · 2024Article
- The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery.GeroScience · 2023Article
- A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds.Biogerontology · 2021Article
- Identification of longevity compounds with minimized probabilities of side effects.Biogerontology · 2020Article
- Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging.Cell reports · 2019Article
- Article
- Geroprotectors: A Unified Concept and Screening Approaches.Aging and disease · 2017Review
- Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks.BMC systems biology · 2016Article
- Chemical activation of a food deprivation signal extends lifespan.Aging cell · 2016Article
- Mood, stress and longevity: convergence on ANK3.Molecular psychiatry · 2016Article
- Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.Aging cell · 2016Review
- Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen inFrontiers in pharmacology · 2016Article
- Geroscience approaches to increase healthspan and slow aging.F1000Research · 2016Review
- Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.F1000Research · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
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Registered trials
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