ReviewFrontiers in immunology2015
Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More?
Review in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance.Immunology · 2026Review
- Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen-Driven Autoimmunity.Immunological reviews · 2026Review
- The Thymus as a Mirror of the Body's Gene Expression.Advances in experimental medicine and biology · 2025Review
- Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis.Frontiers in immunology · 2024Review
- The single-cell transcriptome of mTECs and CD4Frontiers in immunology · 2024Article
- Review
- Ehf and Fezf2 regulate late medullary thymic epithelial cell and thymic tuft cell development.Frontiers in immunology · 2023Article
- Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages.eLife · 2022Article
- Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.Frontiers in endocrinology · 2022Article
- Coxsackievirus B4 Transplacental Infection Severely Disturbs Central Tolerogenic Mechanisms in the Fetal Thymus.Microorganisms · 2021Article
- Self-Peptidome Variation Shapes Individual Immune Responses.Trends in genetics : TIG · 2021Review
- Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.Genome medicine · 2020Article
- Aire Gene Influences the Length of the 3' UTR of mRNAs in Medullary Thymic Epithelial Cells.Frontiers in immunology · 2020Article
- Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis.Journal of neuroinflammation · 2019Article
- Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation.Journal of autoimmunity · 2018Article
- Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality.Frontiers in immunology · 2018Article
- Update on Aire and thymic negative selection.Immunology · 2018Review
- Twenty Years of AIRE.Frontiers in immunology · 2018Review
- Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes.Frontiers in immunology · 2018Article
- Environmental Factors Contribute to β Cell Endoplasmic Reticulum Stress and Neo-Antigen Formation in Type 1 Diabetes.Frontiers in endocrinology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The induction of central tolerance in the course of T cell development crucially depends on promiscuous gene expression (pGE) in medullary thymic epithelial cells (mTECs). mTECs express a genome-wide variety of tissue-restricted antigens (TRAs), preventing the escape of autoreactive T cells to the periphery, and the development of severe autoimmunity. Most of our knowledge of how pGE is controlled comes from studies on the autoimmune regulator (Aire). Aire activates the expression of a large subset of TRAs by interacting with the general transcriptional machinery and promoting transcript elongation. However, further factors regulating Aire-independent TRAs must be at play. Recent studies demonstrated that pGE in general and the function of Aire in particular are controlled by epigenetic and post-transcriptional mechanisms. This mini-review summarizes current knowledge of the regulation of pGE by miRNA and epigenetic regulatory mechanisms such as DNA methylation, histone modifications, and chromosomal topology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.