ArticleFrontiers in psychiatry2015
Decreased Resting-State Connectivity between Neurocognitive Networks in Treatment Resistant Depression.
Article in Frontiers in psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Defining biotypes for depression and anxiety based on large-scale circuit dysfunction: a theoretical review of the evidence and future directions for clinical translation.Depression and anxiety · 2017Pooled it
- Trial
- Effects of electroconvulsive therapy on cerebellar-cerebral functional connectivity in patients with treatment-resistant depression and their correlations with gene expression profiles.Psychiatry and clinical neurosciences · 2026Article
- Impaired regional structure-function coupling as novel neurophenotype: mechanistic insights and diagnostic exploration in treatment-resistant depression.Npj mental health research · 2026Article
- Genetics and Neurobiology of Treatment-Resistant Depression-A Review.International journal of molecular sciences · 2025Review
- Differences in High-Frequency Connectivity Among Large-Scale Functional Networks Linked to Major Depressive Disorder and Treatment-Resistant Depression.Biological psychiatry global open science · 2025Article
- Complex Patterns of Altered White Matter Structural Connectivity within a 'subjective valuation network' in Treatment-Resistant Depression.bioRxiv : the preprint server for biology · 2025Article
- Over-integration of visual network in major depressive disorder and its association with gene expression profiles.Translational psychiatry · 2025Article
- Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.BMC psychiatry · 2023Article
- Functional MRI markers for treatment-resistant depression: Insights and challenges.Progress in brain research · 2023Review
- Resting state functional connectivity as a marker of internalizing disorder onset in high-risk youth.Scientific reports · 2022Article
- Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study.Brain sciences · 2022Article
- Immediate Modulation of Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2022Article
- Altered functional connectivity in first-episode and recurrent depression: A resting-state functional magnetic resonance imaging study.Frontiers in neurology · 2022Article
- A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults.Frontiers in neuroscience · 2022Article
- Altered Brain Function in Treatment-Resistant and Non-treatment-resistant Depression Patients: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2022Article
- Functional connectivity between the amygdala and subgenual cingulate gyrus predicts the antidepressant effects of ketamine in patients with treatment-resistant depression.Neuropsychopharmacology reports · 2021Article
- Article
- Differential Modulating Effect of Acupuncture in Patients With Migraine Without Aura: A Resting Functional Magnetic Resonance Study.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately one-third of patients with major depressive disorder (MDD) do not achieve remission after various treatment options and develop treatment resistant depression (TRD). So far, little is known about the pathophysiology of TRD. Studies in MDD patients showed aberrant functional connectivity (FC) of three "core" neurocognitive networks: the salience network (SN), cognitive control network (CCN), and default mode network (DMN). We used a cross-sectional design and performed resting-state FC MRI to assess connectivity of the SN, CCN, and both anterior and posterior DMN in 17 severe TRD, 18 non-TRD, and 18 healthy control (HC) subjects. Relative to both non-TRD and HC subjects, TRD patients showed decreased FC between the dorsolateral prefrontal cortex and angular gyrus, which suggests reduced FC between the CCN and DMN, and reduced FC between the medial prefrontal cortex and precuneus/cuneus, which suggests reduced FC between the anterior and posterior DMN. No significant differences in SN FC were observed. Our results suggest that TRD is characterized by a disturbance in neurocognitive networks relative to non-TRD and HC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.