ArticleFrontiers in human neuroscience2015
The trajectory of gray matter development in Broca's area is abnormal in people who stutter.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Language outcome related to brain structures in school-aged preterm children: A systematic review.PloS one · 2018Pooled it
- Exploring Photobiomodulation as a Potential Novel Intervention for Developmental Stuttering: A Review and Hypothesis.Journal of clinical medicine · 2026Review
- The Speech Network in Childhood Stuttering: Differences in Functional Connectivity of the Planning and Motor Loops.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Brain anatomy differences in Chinese children who stutter: a preliminary study.Frontiers in neurology · 2025Article
- Localization of stuttering based on causal brain lesions.Brain : a journal of neurology · 2024Article
- A comparison of structural morphometry in children and adults with persistent developmental stuttering.Brain communications · 2023Article
- A framework For brain atlases: Lessons from seizure dynamics.NeuroImage · 2022Article
- Atypical development of Broca's area in a large family with inherited stuttering.Brain : a journal of neurology · 2022Article
- Structural brain network topological alterations in stuttering adults.Brain communications · 2022Article
- Multimodal explainable AI predicts upcoming speech behavior in adults who stutter.Frontiers in neuroscience · 2022Article
- The Neural Circuitry Underlying the "Rhythm Effect" in Stuttering.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Theta Modulated Neural Phase Coherence Facilitates Speech Fluency in Adults Who Stutter.Frontiers in human neuroscience · 2019Article
- What Are Predictors for Persistence in Childhood Stuttering?Seminars in speech and language · 2018Review
- Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter.Brain : a journal of neurology · 2018Article
- An fNIRS-Based Feature Learning and Classification Framework to Distinguish Hemodynamic Patterns in Children Who Stutter.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018Article
- White matter tractography of the neural network for speech-motor control in children who stutter.Neuroscience letters · 2018Article
- Planum temporale asymmetry in people who stutter.Journal of fluency disorders · 2018Article
- Anomalous network architecture of the resting brain in children who stutter.Journal of fluency disorders · 2018Article
- Auditory-motor adaptation is reduced in adults who stutter but not in children who stutter.Developmental science · 2018Article
- Structural connectivity of right frontal hyperactive areas scales with stuttering severity.Brain : a journal of neurology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The acquisition and mastery of speech-motor control requires years of practice spanning the course of development. People who stutter often perform poorly on speech-motor tasks thereby calling into question their ability to establish the stable neural motor programs required for masterful speech-motor control. There is evidence to support the assertion that these neural motor programs are represented in the posterior part of Broca's area, specifically the left pars opercularis. Consequently, various theories of stuttering causation posit that the disorder is related to a breakdown in the formation of the neural motor programs for speech early in development and that this breakdown is maintained throughout life. To date, no study has examined the potential neurodevelopmental signatures of the disorder across pediatric and adult populations. The current study aimed to fill this gap in our knowledge. We hypothesized that the developmental trajectory of cortical thickness in people who stutter would differ across the lifespan in the left pars opercularis relative to a group of control participants. We collected structural magnetic resonance images from 116 males (55 people who stutter) ranging in age from 6 to 48 years old. Differences in cortical thickness across ages and between patients and controls were investigated in 30 brain regions previously implicated in speech-motor control. An interaction between age and group was found for the left pars opercularis only. In people who stutter, the pars opercularis did not demonstrate the typical maturational pattern of gradual gray matter thinning with age across the lifespan that we observed in control participants. In contrast, the developmental trajectory of gray matter thickness in other regions of interest within the neural network for speech-motor control was similar for both groups. Our findings indicate that the developmental trajectory of gray matter in left pars opercularis is abnormal in people who stutter.
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