Evidence map›Paper›PMID 25784839›Full record

ArticleContemporary oncology (Poznan, Poland)2014

Cyclooxygenase-2 immunohistochemical expression in serrated polyps of the colon.

Miroslaw Kiedrowski, Andrzej Mroz, Ewa Kraszewska, Alina Rembiszewska, Anna Felisiak-Golabek, Jolanta Kupryjanczyk, Andrzej Deptala, Janina Orlowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Miroslaw KiedrowskiClinical Department of Oncology and Hematology, Central Clinical Hospital of the Ministry of Interior in Warsaw, Poland ; Department of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Andrzej MrozDepartment of Gastroenterology and Hepatology, Center of Postgraduate Medical Education, Warsaw, Poland.
Ewa KraszewskaDepartment of Gastroenterology and Hepatology, Center of Postgraduate Medical Education, Warsaw, Poland.
Alina RembiszewskaDepartment of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Anna Felisiak-GolabekDepartment of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jolanta KupryjanczykDepartment of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Andrzej DeptalaClinical Department of Oncology and Hematology, Central Clinical Hospital of the Ministry of Interior in Warsaw, Poland ; Department of Cancer Prevention, Medical University of Warsaw, Warsaw, Poland.
Janina OrlowskaDepartment of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
The Maria Sklodowska-Curie National Research Institute of Oncology · PLCentral Clinical Hospital · PLPostgraduate School of Molecular Medicine · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyCyclooxygenase-2 (COX-2) expression has been observed in a substantial percentage of classical adenomas of the large bowel. The aim of the study was to assess and compare the expression of COX-2 in serrated polyps of the colon. MATERIAL AND

methodsOne hundred and nineteen serrated polyps were analyzed. There were 83 hyperplastic polyps (HP), 19 sessile serrated polyps (SSP) and 17 traditional serrated adenomas (TSA). COX-2 expression was assessed semi-quantitatively (0-2) and each lesion was fully characterized in terms of anatomical location, size, histology, age and sex of the patient. The general estimating equation (GEE) model with logit link was used in the statistical analysis.

resultsEpithelial expression of COX-2 was found in 85/119 serrated polyps (71.43%): 57/83 (68.67%) HP, 16/19 (84.21%) SSP, and 12/17 (70.59%) TSA. In HP and SSP it was predominantly of weak (49/83 HP, 12/19 SSP), whereas in TSA it was mainly of medium/strong intensity (8/17). The TSA category was associated with more frequent COX-2 expression (OR = 7.00, 95% CI: 1.49-32.88, p = 0.014) than HP, but such relation was not found for SSP vs. HP (p > 0.1). No associations between COX-2 expression and clinical parameters were found.

conclusionsImmunohistochemical COX-2 expression cannot serve as a diagnostic adjunct to differentiate HP and SSP.

Indexed as

cyclooxygenase-2hyperplastic polypserrated neoplasiasessile serrated polyptraditional serrated adenoma

Identifiers

PMID25784839
PMCPMC4355662
OpenAlexW2320306332

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.