ArticleAmerican journal of clinical oncology2017
Alcohol Abuse Decreases Pelvic Control and Survival in Cervical Cancer: An Opportunity of Lifestyle Intervention for Outcome Improvement.
Article in American journal of clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Health Behaviors in Cervical Cancer Survivors and Associations with Quality of Life.Clinical therapeutics · 2016Trial
- Social inequities and clinical outcomes in young women with cervical cancer: Real-world evidence.PloS one · 2026Article
- Survival beyond treatment: patterns and determinants of disease-free survival in cervical cancer at a tertiary care center in India.Frontiers in oncology · 2026Article
- Review
- Cervical cancer mortality trend in Montenegro-1990-2018.European journal of public health · 2025Article
- Coping strategies utilized by patients with cervical cancer: an explorative qualitative study at the Ocean Road Cancer Institute in Dar es Salaam, Tanzania.BMC women's health · 2025Article
- The relationship between long non-coding geneCancer biology & therapy · 2024Article
- Preventive behaviors and behavioral risk factors among gynecologic cancer survivors: Results from the 2020 Behavioral Risk Factor Surveillance System Survey.Cancer medicine · 2023Article
- Effect of Ethanol-Induced Methyl Donors Consumption on the State of Hypomethylation in Cervical Cancer.International journal of molecular sciences · 2023Article
- Patterns of cigarette smoking and alcohol drinking among Canadian adults with cancer in a contemporary national cohort.Journal of cancer survivorship : research and practice · 2023Article
- A national study of alcohol consumption patterns among population-based U.S. cancer survivors compared with cancer-free individuals.Cancer epidemiology · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeWe examined the incidence and the effect of alcohol abuse on pelvic control (PC), disease-free survival (DFS), and overall survival (OS) in locally advanced cervical cancer patients undergoing definitive radiation therapy (RT).
methodsBetween 2007 and 2013, 95 patients treated with RT were reviewed, and the tumor characteristics, the RT dose, the treatment time, chemotherapy, and the number of cycles were recorded. The association between alcohol abuse and DFS, OS, and the duration of PC was analyzed using multivariable Cox proportional hazards models.
resultsOf the 95 patients with an average age of 54.8 years (range, 27 to 91 y), 30% were FIGO stage 1B1, 1B2, 2A, 52% stage 2B, 3A; and 18% stage 3B; 86% of the patients were treated with weekly cisplatin chemotherapy. Alcohol history showed that 10 (10.5%) patients met the CDC criteria for heavy alcohol use. With a mean follow-up time of 2 years, 85 patients (88.5%) achieved PC and 86 patients (90.5%) were free of distant metastasis. A total of 82 patients (86.3%) were alive at the last follow-up. When controlling for the total treatment time, excessive alcohol abuse was significantly associated with a decrease in DFS (P=0.005; hazard ratio [HR], 6.19; 95% confidence interval [CI]: 1.73, 22.18), OS (P=0.001; HR, 6.68; 95% CI: 2.10, 21.26), and PC (P=0.029; HR, 3.10; 95% CI: 1.13, 8.56) on univariable analysis. On multivariable analysis, excessive alcohol abuse was significantly associated with a decrease in DFS (P=0.005; HR, 10.57; 95% CI: 2.07, 53.93) and OS (P=0.001; HR, 10.80; 95% CI: 2.57, 45.40).
conclusionsIn this small hypothesis-generating series of patients with heavy alcohol use, the data support the association that heavy alcohol use increases the risk of cancer recurrence and mortality. Additional research is required to better define the patient- and treatment-related factors that may be targeted for intervention.
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