ArticleThe Journal of biological chemistry2015
The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Role of photolyase in stress tolerance and virulence of plant-pathogenic bacteriumApplied and environmental microbiology · 2026Article
- A structural decryption of cryptochromes.Frontiers in chemistry · 2024Review
- Dynamic interplays between three redox cofactors in a DNA photolyase revealed by spectral decomposition.Cell reports. Physical science · 2023Article
- Insights into Molecular Structure of Pterins Suitable for Biomedical Applications.International journal of molecular sciences · 2022Review
- Article
- Limited solvation of an electron donating tryptophan stabilizes a photoinduced charge-separated state in plant (6-4) photolyase.Scientific reports · 2022Article
- A putative bifunctional CPD/ (6-4) photolyase from the cyanobacteriaFrontiers in microbiology · 2022Article
- Identification of a Novel Class of Photolyases as Possible Ancestors of Their Family.Molecular biology and evolution · 2021Article
- Structural insights into photoactivation of plant Cryptochrome-2.Communications biology · 2021Article
- A topologically distinct class of photolyases specific for UV lesions within single-stranded DNA.Nucleic acids research · 2020Article
- A Case Study of Eukaryogenesis: The Evolution of Photoreception by Photolyase/Cryptochrome Proteins.Journal of molecular evolution · 2020Article
- Enhanced DNA repair by DNA photolyase bearing an artificial light-harvesting chromophore.Nucleic acids research · 2020Article
- A highly efficient and cost-effective recombinant production of a bacterial photolyase from the Antarctic isolate Hymenobacter sp. UV11.Extremophiles : life under extreme conditions · 2019Article
- Article
- Functional role of an unusual tyrosine residue in the electron transfer chain of a prokaryotic (6-4) photolyase.Chemical science · 2018Article
- Photolyase: Dynamics and electron-transfer mechanisms of DNA repair.Archives of biochemistry and biophysics · 2017Review
- Insights into the red algae and eukaryotic evolution from the genome ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- New insights into marine group III Euryarchaeota, from dark to light.The ISME journal · 2017Article
- Searching for novel photolyases in UVC-resistant Antarctic bacteria.Extremophiles : life under extreme conditions · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photolyases are proteins with an FAD chromophore that repair UV-induced pyrimidine dimers on the DNA in a light-dependent manner. The cyclobutane pyrimidine dimer class III photolyases are structurally unknown but closely related to plant cryptochromes, which serve as blue-light photoreceptors. Here we present the crystal structure of a class III photolyase termed photolyase-related protein A (PhrA) of Agrobacterium tumefaciens at 1.67-Å resolution. PhrA contains 5,10-methenyltetrahydrofolate (MTHF) as an antenna chromophore with a unique binding site and mode. Two Trp residues play pivotal roles for stabilizing MTHF by a double π-stacking sandwich. Plant cryptochrome I forms a pocket at the same site that could accommodate MTHF or a similar molecule. The PhrA structure and mutant studies showed that electrons flow during FAD photoreduction proceeds via two Trp triads. The structural studies on PhrA give a clearer picture on the evolutionary transition from photolyase to photoreceptor.
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