ArticleInfection and immunity1985
Effect of liposomal amphotericin B on murine macrophages and lymphocytes.
Article in Infection and immunity, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis.Medical mycology case reports · 2021Article
- Clinical Translation of Nanomedicine.Chemical reviews · 2015Review
- Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis in late adulthood.The American journal of tropical medicine and hygiene · 2013Article
- Voriconazole inhibits fungal growth without impairing antigen presentation or T-cell activation.Antimicrobial agents and chemotherapy · 2003Article
- Influence of liposomal amphotericin B on CD8 T-cell function.Antimicrobial agents and chemotherapy · 2001Article
- Enhanced intramacrophage activity of resorcinomycin A against Mycobacterium avium-Mycobacterium intracellulare complex after liposome encapsulation.Antimicrobial agents and chemotherapy · 1996Article
- Carrier effects on biological activity of amphotericin B.Clinical microbiology reviews · 1996Review
- Liposome encapsulation of clofazimine reduces toxicity in vitro and in vivo and improves therapeutic efficacy in the beige mouse model of disseminated Mycobacterium avium-M. intracellulare complex infection.Antimicrobial agents and chemotherapy · 1996Article
- Anticryptococcal effect of amphotericin B is mediated through macrophage production of nitric oxide.Antimicrobial agents and chemotherapy · 1996Article
- Immunological effects of amphotericin B and liposomal amphotericin B on splenocytes from immune-normal and immune-compromised mice.Antimicrobial agents and chemotherapy · 1993Article
- In vitro models for studying toxicity of antifungal agents.Antimicrobial agents and chemotherapy · 1992Review
- Effects of amphotericin B and fluconazole on the extracellular and intracellular growth of Candida albicans.Antimicrobial agents and chemotherapy · 1991Article
- Liposomal amphotericin B inhibits in vitro T-lymphocyte response to antigen.Antimicrobial agents and chemotherapy · 1991Article
- Improvement of amphotericin B activity during experimental cryptococcosis by incorporation into specific immunoliposomes.Antimicrobial agents and chemotherapy · 1990Article
- Activity of amphotericin B and intraconazole against intraphagocytic Candida albicans.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1990Article
- Liposomes in treatment of infectious diseases.Pharmaceutisch weekblad. Scientific edition · 1987Review
- Liposomes as carriers of antimicrobial agents.Antimicrobial agents and chemotherapy · 1987Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of liposome-encapsulated amphotericin B on mouse macrophages and on T- and B-lymphocyte functions in vitro was compared with that of free amphotericin B. Liposomal amphotericin B was generally less toxic than the free form of the drug. Low concentrations of free amphotericin B completely inhibited the serum-dependent induction of transglutaminase, a marker for macrophage differentiation, and production of superoxide anion by macrophages, whereas encapsulation of the drug within liposomes protected the cells from these adverse effects. Liposomal amphotericin B did not affect the blastogenic response of T cells compared with the free drug, which was inhibitory at high concentrations. Antibody production in vivo was inhibited partially by both free and liposomal amphotericin B. These results thus suggest that encapsulation of amphotericin B in liposomes reduces the immunosuppressive effects exerted by free amphotericin B. This provides further justification for therapeutic use of liposomal amphotericin B in systemic fungal infections (G. Lopez-Berestein, R. Mehta, R. L. Hopfer, K. Mills, L. Kasi, K. Mehta, V. Fainstein, M. Luna, E. M. Hersh, and R. L. Juliano, J. Infect. Dis. 147:939-945, 1983).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.