Evidence map›Paper›PMID 25784146›Full record

ArticleClinical immunology (Orlando, Fla.)2015

Increased CD1c+ mDC1 with mature phenotype regulated by TNFα-p38 MAPK in autoimmune ocular inflammatory disease.

Ping Chen, Alastair Denniston, Susan Hannes, William Tucker, Lai Wei, Baoying Liu, Tiaojiang Xiao, Sima Hirani, Zhiyu Li, Shayma Jawad and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ping ChenLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Alastair DennistonOphthalmology Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHSFT, Edgbaston, Birmingham B15 2WB, UK; Centre for Translational Inflammation Research, University of Birmingham, UK.
Susan HannesLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
William TuckerLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Lai WeiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Baoying LiuLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Tiaojiang XiaoLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sima HiraniLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Zhiyu LiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shayma JawadLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Han SiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Richard W J LeeDepartment of Clinical Sciences, University of Bristol, Bristol, UK.
H Nida SenLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Robert B NussenblattLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: nussenblattr@nei.nih.gov.
National Institutes of Health · USNational Eye Institute · USUniversity of Birmingham · GBUniversity of Bristol · GB

Funding

Uveitis and Ocular Immunology FellowshipZIEEY000482 · NEI · NATIONAL EYE INSTITUTE · PI KODATI, SHILPA · 2009 to 2022
$4.6M
Cellular and molecular mechanisms in Age Related Macular Degeneration & UveitisZIAEY000464 · NEI · NATIONAL EYE INSTITUTE · PI CHAIGNE-DELALANDE, BENJAMIN · 2009 to 2016
$2.4M
Use Of Microarrays and Epigenetics In Gene Expression Of Uveitis & AMD PatientsZIAEY000376 · NEI · NATIONAL EYE INSTITUTE · PI CHAIGNE-DELALANDE, BENJAMIN · 2009 to 2016
$2.1M
ORAL ADMINISTRATION OF ANTIGEN AND THE OCULAR IMMUNE RESPONSEZIAEY000278 · NEI · NATIONAL EYE INSTITUTE · PI NUSSENBLATT, ROBERT · 2010 to 2016
$1.6M
ORAL ADMINISTRATION OF ANTIGEN AND THE OCULAR IMMUNE RESPONSEZ01EY000278 · NEI · NATIONAL EYE INSTITUTE · PI NUSSENBLATT, RB B · 1992 to 1997
–
Intramural NIH HHS Z01 EY000278Intramural NIH HHS Z99 EY999999Medical Research Council G0600416
6 · The paper itself

Abstract

In this study we investigated the role of blood CD1c(+) myeloid dendritic cells 1 (mDC1), a key mDC subtype, in patients with autoimmune uveitis. We observed a significant increase of blood CD1c(+) mDC1 in uveitis patients. The increased CD1c(+) mDC1 exhibited high HLADR expression and less antigen uptake. CD1c(+) mDC1 were divided into two subpopulations. CD1c(hi) mDC1 subpopulation showed less antigen uptake and higher HLADR expression compared to CD1c(lo) mDC1 subpopulation. Importantly, the CD1c(hi) mDC1 subpopulation was increased in uveitis patients. In vitro, mature monocyte-derived dendritic cells (MoDCs), characterized by lower levels of antigen uptake, induced more CD4(+)CD62L(-) T helper cell proliferation. The mature phenotype and function of CD1c(+) mDC1 were regulated by TNFα via a p38 MAPK-dependent pathway. These data show that alterations in the systemic immune response are involved in the pathogenesis of autoimmune uveitis and invite the therapeutic possibility of attenuating uveitis by manipulating blood CD1c(+) mDC1.

Indexed as

AdolescentAdultAgedAntigens, CD1Autoimmune DiseasesDendritic CellsFemaleGlycoproteinsHumansMaleMiddle AgedMyeloid Cellsp38 Mitogen-Activated Protein KinasesSignal TransductionT-Lymphocytes, Helper-InducerTumor Necrosis Factor-alphaAntigens, CD1CD1C protein, humanGlycoproteinsp38 Mitogen-Activated Protein KinasesTumor Necrosis Factor-alphaAntigen uptakeAutoimmune uveitisCD1c(hi) mDC1 subpopulationCD1c(+) mDC1p38 MAPKTNFα

Identifiers

PMID25784146
PMCPMC4420697
OpenAlexW1999325377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.