ArticleHearing research2015
Aminoglycoside ototoxicity and hair cell ablation in the adult gerbil: A simple model to study hair cell loss and regeneration.
Article in Hearing research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Suppression of the TGF-β signaling exacerbates degeneration of auditory neurons in kanamycin-induced ototoxicity in mice.Scientific reports · 2024Article
- Article
- Association between Simultaneous Occurrence of Occupational Noise-Induced Hearing Loss and Noise-Induced Vestibular Dysfunction: A Systematic Review.Iranian journal of public health · 2023Review
- Identifying targets to prevent aminoglycoside ototoxicity.Molecular and cellular neurosciences · 2022Review
- Reactivation of the Neurogenic Niche in the Adult Zebrafish Statoacoustic Ganglion Following a Mechanical Lesion.Frontiers in cell and developmental biology · 2022Article
- Experimental animal models of drug-induced sensorineural hearing loss: a narrative review.Annals of translational medicine · 2021Review
- Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration.Development (Cambridge, England) · 2019Review
- Hair cell and neural contributions to the cochlear summating potential.Journal of neurophysiology · 2019Article
- A high-density genetic map and molecular sex-typing assay for gerbils.Mammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- Wound healing mechanism in Mongolian gerbil skin.Histochemistry and cell biology · 2019Article
- Drug-Induced Ototoxicity: Diagnosis and Monitoring.Drug safety · 2018Review
- Inbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies.G3 (Bethesda, Md.) · 2018Article
- Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation.Scientific reports · 2018Article
- Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model.BioMed research international · 2018Article
- Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death.Frontiers in cellular neuroscience · 2017Review
- Article
- A Simple Model for Inducing Optimal Increase ofBioMed research international · 2017Article
- Electrophysiological detection of scalar changing perimodiolar cochlear electrode arrays: a long term follow-up study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Mongolian gerbil, Meriones unguiculatus, has been widely employed as a model for studies of the inner ear. In spite of its established use for auditory research, no robust protocols to induce ototoxic hair cell damage have been developed for this species. In this paper, we demonstrate the development of an aminoglycoside-induced model of hair cell loss, using kanamycin potentiated by the loop diuretic furosemide. Interestingly, we show that the gerbil is relatively insensitive to gentamicin compared to kanamycin, and that bumetanide is ineffective in potentiating the ototoxicity of the drug. We also examine the pathology of the spiral ganglion after chronic, long-term hair cell damage. Remarkably, there is little or no neuronal loss following the ototoxic insult, even at 8 months post-damage. This is similar to the situation often seen in the human, where functioning neurons can persist even decades after hair cell loss, contrasting with the rapid, secondary degeneration found in rats, mice and other small mammals. We propose that the combination of these factors makes the gerbil a good model for ototoxic damage by induced hair cell loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.