Evidence map›Paper›PMID 25783765›Full record

Trial reportScientific reports2015

Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: a randomized controlled trial.

Giovanni Vinetti, Chiara Mozzini, Paolo Desenzani, Enrico Boni, Laura Bulla, Isabella Lorenzetti, Claudia Romano, Andrea Pasini, Luciano Cominacini, Deodato Assanelli

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Giovanni VinettiDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Chiara MozziniDepartment of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy.
Paolo DesenzaniDiabetology Unit, Azienda Ospedaliera Spedali Civili di Brescia, Montichiari, Italy.
Enrico Boni1st Division of General Medicine, Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy.
Laura BullaDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Isabella LorenzettiDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Claudia RomanoDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Andrea PasiniDepartment of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy.
Luciano CominaciniDepartment of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy.
Deodato AssanelliDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
University of Brescia · ITUniversity of Verona · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the effects of supervised exercise training (SET) on cardiometabolic risk, cardiorespiratory fitness and oxidative stress status in 2 diabetes mellitus (T2DM), twenty male subjects with T2DM were randomly assigned to an intervention group, which performed SET in a hospital-based setting, and to a control group. SET consisted of a 12-month supervised aerobic, resistance and flexibility training. A reference group of ten healthy male subjects was also recruited for baseline evaluation only. Participants underwent medical examination, biochemical analyses and cardiopulmonary exercise testing. Oxidative stress markers (1-palmitoyl-2-[5-oxovaleroyl]-sn-glycero-3-phosphorylcholine [POVPC]; 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine [PGPC]) were measured in plasma and in peripheral blood mononuclear cells. All investigations were carried out at baseline and after 12 months. SET yielded a significant modification (p < 0.05) in the following parameters: V'O₂max (+14.4%), gas exchange threshold (+23.4%), waist circumference (-1.4%), total cholesterol (-14.6%), LDL cholesterol (-20.2%), fasting insulinemia (-48.5%), HOMA-IR (-52.5%), plasma POVPC (-27.9%) and PGPC (-31.6%). After 12 months, the control group presented a V'O₂max and a gas exchange threshold significantly lower than the intervention group. Plasma POVC and PGPC were significantly different from healthy subjects before the intervention, but not after. In conclusion, SET was effective in improving cardiorespiratory fitness, cardiometabolic risk and oxidative stress status in T2DM.

Indexed as

Exercise TestAdultAgedBody WeightCholesterolCholesterol, LDLDiabetes Mellitus, Type 2HumansLeukocytes, MononuclearMaleMiddle AgedOxidative StressPhospholipid EthersRisk Factors1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholineCholesterolCholesterol, LDLPhospholipid Ethers

Identifiers

PMID25783765
PMCPMC4363871
OpenAlexW2022355191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.