ArticleGenetics2015
Genetic architecture and functional characterization of genes underlying the rapid diversification of male external genitalia between Drosophila simulans and Drosophila mauritiana.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Heat-mediated manipulation of gene expression by IR-LEGO in the developing genitalia in Drosophila.G3 (Bethesda, Md.) · 2026Article
- A developmental atlas of male terminalia across twelve species ofFrontiers in cell and developmental biology · 2024Article
- Molecular and Developmental Signatures of Genital Size Macro-Evolution in Bugs.Molecular biology and evolution · 2022Article
- Evolution of assortative mating following selective introgression of pigmentation genes between twoEcology and evolution · 2022Article
- Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species.Molecular biology and evolution · 2021Article
- Evolution of Reproductive Behavior.Genetics · 2020Review
- An Atlas of Transcription Factors Expressed in Male Pupal Terminalia ofG3 (Bethesda, Md.) · 2019Article
- Article
- Genetic basis of species-specific genitalia reveals role in species diversification.Science advances · 2019Article
- Quantifying the extent of morphological homoplasy: A phylogenetic analysis of 490 characters inEvolution letters · 2019Article
- Genetic and Transgenic Reagents forG3 (Bethesda, Md.) · 2017Article
- Quantitative Trait Loci and Antagonistic Associations for Two Developmentally Related Traits in the Drosophila Head.Journal of insect science (Online) · 2017Article
- The Genetic Basis of Baculum Size and Shape Variation in Mice.G3 (Bethesda, Md.) · 2016Article
- Mapping QTL Contributing to Variation in Posterior Lobe Morphology between Strains of Drosophila melanogaster.PloS one · 2016Article
- A Major Locus Controls a Genital Shape Difference Involved in Reproductive Isolation Between Drosophila yakuba and Drosophila santomea.G3 (Bethesda, Md.) · 2015Article
- Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster.PloS one · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
Male sexual characters are often among the first traits to diverge between closely related species and identifying the genetic basis of such changes can contribute to our understanding of their evolutionary history. However, little is known about the genetic architecture or the specific genes underlying the evolution of male genitalia. The morphology of the claspers, posterior lobes, and anal plates exhibit striking differences between Drosophila mauritiana and D. simulans. Using QTL and introgression-based high-resolution mapping, we identified several small regions on chromosome arms 3L and 3R that contribute to differences in these traits. However, we found that the loci underlying the evolution of clasper differences between these two species are independent from those that contribute to posterior lobe and anal plate divergence. Furthermore, while most of the loci affect each trait in the same direction and act additively, we also found evidence for epistasis between loci for clasper bristle number. In addition, we conducted an RNAi screen in D. melanogaster to investigate if positional and expression candidate genes located on chromosome 3L, are also involved in genital development. We found that six of these genes, including components of Wnt signaling and male-specific lethal 3 (msl3), regulate the development of genital traits consistent with the effects of the introgressed regions where they are located and that thus represent promising candidate genes for the evolution these traits.
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