ArticleAlimentary pharmacology & therapeutics2015
A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease.
Article in Alimentary pharmacology & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders.Frontiers in immunology · 2023Pooled it
- Quality of life in primary sclerosing cholangitis: a systematic review.Health and quality of life outcomes · 2021Pooled it
- Patient-reported outcome measures used in patients with primary sclerosing cholangitis: a systematic review.Health and quality of life outcomes · 2018Pooled it
- Dietary Habits of Individuals With Primary Sclerosing Cholangitis-Poor Fat-Soluble Vitamin Intake and Dietary Quality.Liver international : official journal of the International Association for the Study of the Liver · 2025Trial
- Dietary and Lifestyle Risk Factors in Primary Sclerosing Cholangitis: In Search of Mechanistic Explanations and Health Improvement.The Journal of nutrition · 2025Review
- Fecal deoxycholic acid associates with diet, intestinal microbes, and total bilirubin in primary sclerosing cholangitis.JHEP reports : innovation in hepatology · 2024Article
- Elevated Liver Fibrosis Progression in Isolated PSC Patients and Increased Malignancy Risk in a PSC-IBD Cohort: A Retrospective Study.International journal of molecular sciences · 2023Article
- Patients with Autoimmune Hepatitis Report Lower Lifetime Coffee Consumption.Digestive diseases and sciences · 2022Article
- Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods.Environmental health perspectives · 2022Article
- A Review on Biomarkers for the Evaluation of Autoimmune Cholestatic Liver Diseases and Their Overlap Syndromes.Frontiers in molecular medicine · 2022Review
- Environmental risk factors are associated with autoimmune hepatitis.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- The PSC scientific community resource: an asset for multi-omics interrogation of primary sclerosing cholangitis.BMC gastroenterology · 2021Article
- Geo-epidemiology and environmental co-variate mapping of primary biliary cholangitis and primary sclerosing cholangitis.JHEP reports : innovation in hepatology · 2021Article
- [Novel Insights of Primary Sclerosing Cholangitis and Primary Biliary Cholangitis].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2020Review
- Studying the Exposome to Understand the Environmental Determinants of Complex Liver Diseases.Hepatology (Baltimore, Md.) · 2020Review
- Novel HLA Class I Alleles Outside the Extended DR3 Haplotype Are Protective against Autoimmune Hepatitis.Clinical and translational gastroenterology · 2019Article
- Association between smoking and risk of primary sclerosing cholangitis: A systematic review and meta-analysis.United European gastroenterology journal · 2018Article
- Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018Article
- The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease.United European gastroenterology journal · 2018Article
- Autoimmune liver disease and the enteric microbiome.AIMS microbiology · 2018Review
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Authors and funding
15 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundThe relationships between primary sclerosing cholangitis (PSC) and the environment are largely unknown.
aimTo validate associations reported in previous studies and to identify novel environmental exposures among PSC patients.
methodsWe performed a multicenter, case-control analysis utilising self-administered questionnaires. Responses between cases (n = 1000) and controls (n = 663) were compared using multivariable logistic regression adjusted for age and gender. The model was further stratified based on inflammatory bowel disease (IBD) status (with IBD n = 741 without IBD n = 259).
resultsSmoking was associated with PSC only when IBD was present (OR, 0.5; 95% CI 0.4-0.7) but not among those PSC patients without IBD (OR, 0.9; 95% CI 0.7-1.2). Compared to controls, women with PSC (irrespective of the presence of IBD) were less likely to have received hormone replacement therapy (HRT; OR, 0.5; 95% CI 0.4-0.7) and were more likely to have recurrent urinary tract infections (OR, 1.6; 95% CI 1.2-2.3). PSC patients regardless of gender or IBD status were less likely to eat fish (OR, 0.4; 95% CI 0.3-0.6) and grilled/barbecued meat (OR, 0.8; 95% CI 0.7-0.9). In contrast, PSC patients with and without IBD were more likely to consume steak/burgers that were more well done (OR, 1.3; 95% CI 1.2-1.5).
conclusionsIBD (rather than PSC) is associated with smoking. Women with PSC are more likely to have recurrent urinary tract infections and less likely to receive HRT. Dietary intake and methods of food preparation differ in PSC patients when compared to controls.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.