ArticleHeart and vessels2016
A novel susceptibility locus for Takayasu arteritis in the IL12B region can be a genetic marker of disease severity.
Article in Heart and vessels, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy.Scientific reports · 2017Pooled it
- Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu Arteritis.Journal of extracellular biology · 2026Article
- Advances in Takayasu arteritis: An Asia Pacific perspective.Frontiers in medicine · 2022Review
- Plasma apolipopotein C-2 elevation is associated with Takayasu arteritis.Scientific reports · 2021Observational
- A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis.Scientific reports · 2021Article
- Roles of cytotoxic lymphocytes and MIC/LILR families in pathophysiology of Takayasu arteritis.Inflammation and regeneration · 2020Review
- Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.Circulation. Genomic and precision medicine · 2018Article
- Bioinformatic Analysis Identifies Three Potentially Key Differentially Expressed Genes in Peripheral Blood Mononuclear Cells of Patients with Takayasu's Arteritis.Cell journal · 2018Article
- A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production.Arthritis research & therapy · 2017Article
- Single nucleotide polymorphisms of IL12B are associated with Takayasu arteritis in Chinese Han population.Rheumatology international · 2017Article
- Comparison of clinical characteristics in patients with Takayasu arteritis with and without concomitant tuberculosis.Heart and vessels · 2016Article
- Lack of association between polymorphisms in interleukin (IL)-12, IL-12R, IL-23, IL-23R genes and Takayasu arteritis in a Chinese population.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Revisited HLA and non-HLA genetics of Takayasu arteritis--where are we?Journal of human genetics · 2016Review
- Giant cell arteritis versus Takayasu's Arteritis: Two sides of the same coin?Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- The genetics of Takayasu arteritis.Presse medicale (Paris, France : 1983)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Takayasu arteritis (TAK) is an acute and chronic vasculitis of unknown etiology. Recently, our group reported that SNP rs6871626 in the IL12B region had significant association with disease susceptibility to TAK. However, association of the SNP with clinical characteristics of TAK has yet to be determined. Therefore, we assessed whether this SNP was associated with TAK disease severity as represented by early onset and/or refractoriness to medical therapy. A total of 90 patients were genotyped for rs6871626 and their clinical charts were reviewed retrospectively. By examining the relationship between genotype and clinical profiles of patients, we found a strong association between the number of risk alleles and the frequency of severe cases as defined by (1) age at onset <20 years old, (2) steroid resistance, and/or (3) a relapse of disease [p = 0.03; odds ratio 3.75 (95 % confidence interval 1.13-13.5)]. Thus, our study points to potential diagnostic use of SNP rs6871626 for predicting disease severity of TAK, with the goal of genotyping-oriented therapy in the near future.
Indexed as
Identifiers
25783557What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.