ArticleInfection control and hospital epidemiology2015
The cost-benefit of federal investment in preventing Clostridium difficile infections through the use of a multifaceted infection control and antimicrobial stewardship program.
Article in Infection control and hospital epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02951481 (Antimicrobial Stewardship Program Based on the Detection and Monitoring of Patients With Clostridium Difficile Infection), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antimicrobial Stewardship Program Based on the Detection and Monitoring of Patients With Clostridium Difficile Infection (PACTA-ICD)
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health economic studies of antimicrobial stewardship programmes: A scoping review.NIHR open research · 2024Pooled it
- Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review.Antimicrobial resistance and infection control · 2019Pooled it
- Practical Concerns about the Metrics and Methods of Financial Outcome Measurement in Antimicrobial Stewardship Programs: A Narrative Review.Iranian journal of medical sciences · 2022Review
- Clinical impact of aJAC-antimicrobial resistance · 2020Article
- Intestinal bile acids directly modulate the structure and function ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Assessing the social cost and benefits of a national requirement establishing antibiotic stewardship programs to preventAntimicrobial resistance and infection control · 2019Article
- Infection prevention and control ofJournal of global health · 2016Review
- Observational
- Vital Signs: Estimated Effects of a Coordinated Approach for Action to Reduce Antibiotic-Resistant Infections in Health Care Facilities - United States.MMWR. Morbidity and mortality weekly report · 2015Article
- Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy.Risk management and healthcare policy · 2015Article
- Understanding the Economic Impact of Health Care-Associated Infections: A Cost Perspective Analysis.Journal of infusion nursing : the official publication of the Infusion Nurses SocietyArticle
- Leaping Forward in the Treatment ofGE Portuguese journal of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo determine the potential epidemiologic and economic value of the implementation of a multifaceted Clostridium difficile infection (CDI) control program at US acute care hospitals
designMarkov model with a 5-year time horizon
participantsPatients whose data were used in our simulations were limited to hospitalized Medicare beneficiaries ≥65 years old.
backgroundCDI is an important public health problem with substantial associated morbidity, mortality, and cost. Multifaceted national prevention efforts in the United Kingdom, including antimicrobial stewardship, patient isolation, hand hygiene, environmental cleaning and disinfection, and audit, resulted in a 59% reduction in CDI cases reported from 2008 to 2012.
methodsOur analysis was conducted from the federal perspective. The intervention we modeled included the following components: antimicrobial stewardship utilizing the Antimicrobial Use and Resistance module of the National Healthcare Safety Network (NHSN), use of contact precautions, and enhanced environmental cleaning. We parameterized our model using data from CDC surveillance systems, the AHRQ Healthcare Cost and Utilization Project, and literature reviews. To address uncertainty in our parameter estimates, we conducted sensitivity analyses for intervention effectiveness and cost, expenditures by other federal partners, and discount rate. Each simulation represented a cohort of 1,000 hospitalized patients over 1,000 trials. RESULTS In our base case scenario with 50% intervention effectiveness, we estimated that 509,000 CDI cases and 82,000 CDI-attributable deaths would be prevented over a 5-year time horizon. Nationally, the cost savings across all hospitalizations would be $2.5 billion (95% credible interval: $1.2 billion to $4.0 billion).
conclusionsThe potential benefits of a multifaceted national CDI prevention program are sizeable from the federal perspective.
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