ReviewCalcified tissue international2015
The Role of Water Compartments in the Material Properties of Cortical Bone.
Review in Calcified tissue international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
103 citing papers in PubMed, 237 citations in OpenAlex.
- Combination of 3D and 2D Small and Wide Angle X-Ray Scattering Imaging Reveals Diminished Bone Quality in the Superior Human Femoral Neck Cortex.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Bound Water as a Reinforcing Element for Ultra-Strong Polyacrylamide.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Physicochemical Stability of Dentin-Derived Biomaterials During Long-Term Storage.Journal of functional biomaterials · 2026Article
- Identification of water compartment in bone using ATR-FTIR spectroscopy.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2026Article
- Nanomechanical Properties of Rib Bones in Diabetic vs. Healthy Rat Models.Nanomaterials (Basel, Switzerland) · 2025Article
- Hypertension promotes bone loss and fragility by favoring bone resorption in mouse models.The Journal of clinical investigation · 2025Article
- Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity.Current osteoporosis reports · 2025Review
- Impact of three-dimensional stabilization thread design on biomechanical fixation and osseointegration of endosteal implants.Journal of the mechanical behavior of biomedical materials · 2025Article
- Variation and disparity within the inner ear and trigeminus of the tenrecomorpha.Communications biology · 2025Article
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- The Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur.Calcified tissue international · 2025Article
- Biomechanical perspectives on image-based hip fracture risk assessment: advances and challenges.Frontiers in endocrinology · 2025Review
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Are Collagen Protons Visible with the Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequence: A DBioengineering (Basel, Switzerland) · 2024Article
- Bone Quality and Mineralization and Effects of Treatment in Osteogenesis Imperfecta.Calcified tissue international · 2024Review
- One-Pot Hybridization of Microfibrillated Cellulose and Hydroxyapatite as a Versatile Route to Eco-Friendly Mechanical Materials.ACS omega · 2024Article
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- Dose-dependent effects of gamma radiation sterilization on the collagen matrix of human cortical bone allograft and its influence on fatigue crack propagation resistance.Cell and tissue banking · 2024Article
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- Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges.Bone reports · 2024Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Comprising ~20% of the volume, water is a key determinant of the mechanical behavior of cortical bone. It essentially exists in two general compartments: within pores and bound to the matrix. The amount of pore water-residing in the vascular-lacunar-canalicular space-primarily reflects intracortical porosity (i.e., open spaces within the matrix largely due to Haversian canals and resorption sites) and as such is inversely proportional to most mechanical properties of bone. Movement of water according to pressure gradients generated during dynamic loading likely confers hydraulic stiffening to the bone as well. Nonetheless, bound water is a primary contributor to the mechanical behavior of bone in that it is responsible for giving collagen the ability to confer ductility or plasticity to bone (i.e., allows deformation to continue once permanent damage begins to form in the matrix) and decreases with age along with fracture resistance. Thus, dehydration by air-drying or by solvents with less hydrogen bonding capacity causes bone to become brittle, but interestingly, it also increases stiffness and strength across the hierarchical levels of organization. Despite the importance of matrix hydration to fracture resistance, little is known about why bound water decreases with age in hydrated human bone. Using (1)H nuclear magnetic resonance (NMR), both bound and pore water concentrations in bone can be measured ex vivo because the proton relaxation times differ between the two water compartments, giving rise to two distinct signals. There are also emerging techniques to measure bound and pore water in vivo with magnetic resonance imaging (MRI). The NMR/MRI-derived bound water concentration is positively correlated with both the strength and toughness of hydrated bone and may become a useful clinical marker of fracture risk.
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