Evidence map›Paper›PMID 25782980›Full record

ArticleBrain topography2015

Real-Time MEG Source Localization Using Regional Clustering.

Christoph Dinh, Daniel Strohmeier, Martin Luessi, Daniel Güllmar, Daniel Baumgarten, Jens Haueisen, Matti S Hämäläinen

Abstract read
In one paragraph

Article in Brain topography, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
  6. Article
  7. Article
  8. Computationally Efficient Implementation of Aperture Domain Model Image Reconstruction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christoph DinhMassachusetts General Hospital - Massachusetts Institute of Technology - Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, 149 13th St., Charlestown, MA, 02129, USA. chdinh@nmr.mgh.harvard.edu.
Daniel StrohmeierInstitute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Gustav-Kirchhoff-Str. 2, 98693, Ilmenau, Germany.
Martin LuessiMassachusetts General Hospital - Massachusetts Institute of Technology - Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, 149 13th St., Charlestown, MA, 02129, USA.
Daniel GüllmarMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-Universität Jena, Philosophenweg 3, 07743, Jena, Germany.
Daniel BaumgartenInstitute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Gustav-Kirchhoff-Str. 2, 98693, Ilmenau, Germany.
Jens HaueisenInstitute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Gustav-Kirchhoff-Str. 2, 98693, Ilmenau, Germany.
Matti S HämäläinenMassachusetts General Hospital - Massachusetts Institute of Technology - Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, 149 13th St., Charlestown, MA, 02129, USA.

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Tools for Large-Scale Platform-Independent MEG Data AnalysisR01EB009048 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI HAMALAINEN, MATTI, LEAHY, RICHARD M · 2009 to 2016
$4.6M
Elekta Neuromag Electronics UpgradeS10RR031599 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HAMALAINEN, MATTI · 2011 to 2011
$350k
NCRR NIH HHS S10 RR031599NIBIB NIH HHS 2P41EB015896NIBIB NIH HHS 5R01EB009048NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB009048
6 · The paper itself

Abstract

With its millisecond temporal resolution, Magnetoencephalography (MEG) is well suited for real-time monitoring of brain activity. Real-time feedback allows the adaption of the experiment to the subject's reaction and increases time efficiency by shortening acquisition and off-line analysis. Two formidable challenges exist in real-time analysis: the low signal-to-noise ratio (SNR) and the limited time available for computations. Since the low SNR reduces the number of distinguishable sources, we propose an approach which downsizes the source space based on a cortical atlas and allows to discern the sources in the presence of noise. Each cortical region is represented by a small set of dipoles, which is obtained by a clustering algorithm. Using this approach, we adapted dynamic statistical parametric mapping for real-time source localization. In terms of point spread and crosstalk between regions the proposed clustering technique performs better than selecting spatially evenly distributed dipoles. We conducted real-time source localization on MEG data from an auditory experiment. The results demonstrate that the proposed real-time method localizes sources reliably in the superior temporal gyrus. We conclude that real-time source estimation based on MEG is a feasible, useful addition to the standard on-line processing methods, and enables feedback based on neural activity during the measurements.

Indexed as

Brain MappingCluster AnalysisMagnetoencephalographyBrainHumansSignal Processing, Computer-AssistedBrain atlasK-means clusteringMagnetoencephalographyMinimum-norm estimatesReal-timeSource localization

Identifiers

PMID25782980
PMCPMC4575234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.