ArticleMolecular genetics and genomics : MGG2015
Transcriptomic analysis to elucidate the molecular mechanisms that underlie feed efficiency in meat-type chickens.
Article in Molecular genetics and genomics : MGG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Intestinal microbiota-host crosstalk reveals mechanisms regulating residual feed intake in egg-type ducks.BMC genomics · 2026Article
- Characterisation of runs of homozygosity and inbreeding coefficients in the red-brown Korean native chickens.Animal bioscience · 2024Article
- Genetic assessment and candidate genes identification for breed-specific characteristics of Qingyuan partridge chicken based on runs of homozygosity.BMC genomics · 2024Article
- OMICs approaches and technologies for understanding low-high feed efficiency traits in chicken: implication to breeding.Animal biotechnology · 2023Review
- Analysis of Conservation Priorities and Runs of Homozygosity Patterns for Chinese Indigenous Chicken Breeds.Animals : an open access journal from MDPI · 2023Article
- Prune homolog 2 with BCH domain (PRUNE2) gene expression is associated with feed efficiency-related traits in Nelore steers.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Microbiota and Transcriptomic Effects of an Essential Oil Blend and Its Delivery Route Compared to an Antibiotic Growth Promoter in Broiler Chickens.Microorganisms · 2022Article
- Embryonic transcriptome unravels mechanisms and pathways underlying embryonic development with respect to muscle growth, egg production, and plumage formation in native and broiler chickens.Frontiers in genetics · 2022Article
- The significant influence of residual feed intake on flavor precursors and biomolecules in slow-growing Korat chicken meat.Animal bioscience · 2021Article
- Genome-wide association and transcriptome studies identify candidate genes and pathways for feed conversion ratio in pigs.BMC genomics · 2021Article
- Genome-wide analysis reveals the patterns of genetic diversity and population structure of 8 Italian local chicken breeds.Poultry science · 2021Article
- Genome-Wide SNP Analysis Reveals the Population Structure and the Conservation Status of 23 Italian Chicken Breeds.Animals : an open access journal from MDPI · 2020Article
- The association between microbial community and ileal gene expression on intestinal wall thickness alterations in chickens.Poultry science · 2020Article
- Genome-wide Analyses Identifies Known and New Markers Responsible of Chicken Plumage Color.Animals : an open access journal from MDPI · 2020Article
- Expression of genes related to lipid transport in meat-type ducks divergent for low or high residual feed intake.Asian-Australasian journal of animal sciences · 2020Article
- Article
- Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens.Scientific reports · 2019Article
- Effect of divergence in residual feed intake on expression of lipid metabolism-related genes in the liver of meat-type ducks1.Journal of animal science · 2019Article
- Association analysis between feed efficiency and expression of key genes of the avTOR signaling pathway in meat-type ducks.Molecular biology reports · 2019Article
- Transcriptional shifts account for divergent resource allocation in feed efficient broiler chickens.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feed efficiency phenotypes defined by genotypes or gene markers are unknown. To date, there are only limited studies on global gene expression profiling on feed efficiency. The objective of this study was to identify genes and pathways associated with residual feed intake (RFI) through transcriptional profiling of duodenum at two different ages in a chicken population divergently selected for low (LRFI) or high (HRFI) RFI. The global gene expression differences in LRFI and HRFI were assessed by the Affymetrix GeneChip(®) Chicken Genome Array and RT-PCR using duodenal tissue on days 35 and 42. The Ingenuity Pathway Analysis program was used to identify canonical and gene network pathways associated with RFI. A global view of gene expression differences between LRFI and HRFI suggest that RFI can be explained by differences in cell division, growth, proliferation and apoptosis, protein synthesis, lipid metabolism, and molecular transport of cellular molecules. Chickens selected for improved RFI achieve efficiency by reducing feed intake with a nominal or no change in weight gain by either up-regulating CD36, PPARα, HMGCS2, GCG or down-regulating PCSK2, CALB1, SAT1, and SGK1 genes within the lipid metabolism, small molecule biochemistry, molecular transport, cell death, and protein synthesis molecular and cellular functions. Chickens selected for reduced RFI via reduced feed intake with no change in weight gain achieve feed efficiency for growth by the up-regulation of genes that reduce appetite with increased cellular oxidative stress, prolonged cell cycle, DNA damage, and apoptosis in addition to increased oxidation of dietary fat and efficient fatty acids transported from the intestines.
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