ArticleDevelopmental psychobiology2015
Gonadectomy before puberty increases the number of neurons and glia in the medial prefrontal cortex of female, but not male, rats.
Article in Developmental psychobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Sex-specific effects of chronic caffeine on impulsive choice and serotonergic markers in an ADHD rat model.Psychopharmacology · 2026Article
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Hormonal contraceptives in adolescence impact the neuroimmune environment of the medial prefrontal cortex and hippocampus in female rats.Brain, behavior, and immunity · 2025Article
- Membrane progesterone and oestrogen receptors modulate GABAergic transmission in the prefrontal cortex of prepubertal male, but not female, mice.Experimental physiology · 2025Article
- Adolescent Alcohol Exposure Dysregulates Developing Cortical GABA Circuits.Advances in experimental medicine and biology · 2025Review
- Timing of Methamphetamine Exposure during Adolescence Differentially Influences Parvalbumin and Perineuronal Net Immunoreactivity in the Medial Prefrontal Cortex of Female, but Not Male, Rats.Developmental neuroscience · 2025Article
- Disentangling the unique contributions of age, pubertal stage, and pubertal hormones to brain structure in childhood and adolescence.Developmental cognitive neuroscience · 2024Article
- Sex and mental health are related to subcortical brain microstructure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty.Developmental psychobiology · 2024Article
- Attention-deficit/hyperactivity disorder and the menstrual cycle: Theory and evidence.Hormones and behavior · 2024Review
- Sex differences in the distribution and density of regulatory interneurons in the striatum.Frontiers in cellular neuroscience · 2024Article
- White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism.Neuroimage. Reports · 2023Article
- The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats.Physiology & behavior · 2023Review
- Prepubertal ovariectomy confers resilience to stress-induced anxiety in adult female mice.Psychoneuroendocrinology · 2023Article
- Brief postnatal exposure to bisphenol A affects apoptosis and gene expression in the medial prefrontal cortex and social behavior in rats with sex specificity.Neurotoxicology · 2023Article
- Immune signaling in sex-specific neural and behavioral development: Adolescent opportunity.Current opinion in neurobiology · 2022Review
- Changes in sex differences in neuroanatomical structure and cognitive behavior across the life span.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Sex differences in myelin content of white matter tracts in adolescents with depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Coming of age in the frontal cortex: The role of puberty in cortical maturation.Seminars in cell & developmental biology · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The human prefrontal cortex, important for executive functions, loses gray matter throughout the adolescent period. In rats, our laboratory demonstrated that a loss of neurons between adolescence and adulthood partially underlies the loss of volume, and this loss is greater in females than males. Here, we examine whether being deprived of gonadal hormones before puberty through adulthood influences the number of neurons in the medial prefrontal cortex (mPFC). Prior to puberty, the testes or ovaries were removed in male and female rats. In adulthood, the number of neurons and glia in the mPFC were quantified using unbiased stereology, and the volume of the frontal white matter was measured. Prepubertal ovariectomy resulted in a higher number of neurons and glia and a larger volume of white matter compared to sham control littermates. Castrated males were not different from sham males on any measure. Thus ovarian hormones secreted after puberty influence the cellular composition of the medial prefrontal cortex.
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