ArticleNeurocritical care2015
Dynamic Autoregulatory Response After Aneurysmal Subarachnoid Hemorrhage and Its Relation to Angiographic Vasospasm and Clinical Outcome.
Article in Neurocritical care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Impact of Cerebral Autoregulation Monitoring in Cerebrovascular Disease: A Systematic Review.Neurocritical care · 2022Pooled it
- Calcium Channel Blockers in Acute Care: The Links and Missing Links Between Hemodynamic Effects and Outcome Evidence.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Pooled it
- Brain-kidney crosstalk in subarachnoid hemorrhage patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Article
- Assessment of impaired cerebral autoregulation and its correlation with neurological outcome in aneurysmal subarachnoid hemorrhage: A prospective and observational study.Surgical neurology international · 2023Article
- Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation.Physiological reviews · 2021Review
- Cerebral Autoregulation in Subarachnoid Hemorrhage.Frontiers in neurology · 2021Review
- Early Transcranial Doppler Evaluation of Cerebral Autoregulation Independently Predicts Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2019Observational
- Spontaneous Elevation of Blood Pressure After SAH: An Epiphenomenon of Disease Severity and Demand, But Not a Surrogate for Outcome?Neurocritical care · 2018Article
- Cerebral Autoregulation in Stroke.Current atherosclerosis reports · 2018Review
- The Link Between Cerebrovascular Hemodynamics and Rehabilitation Outcomes After Aneurysmal Subarachnoid Hemorrhage.American journal of physical medicine & rehabilitation · 2018Article
- Human cerebrovascular function in health and disease: insights from integrative approaches.Journal of physiological anthropology · 2018Review
- Cerebral Blood Flow Autoregulation in Sepsis for the Intensivist: Why Its Monitoring May Be the Future of Individualized Care.Journal of intensive care medicine · 2018Review
- Increased risk of critical CBF levels in SAH patients with actual CPP below calculated optimal CPP.Acta neurochirurgica · 2017Article
- The effects of ventricular drainage on the intracranial pressure signal and the pressure reactivity index.Journal of clinical monitoring and computing · 2017Article
- High Compliance with Scheduled Nimodipine Is Associated with Better Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Cotreated with Heparin Infusion.Frontiers in neurology · 2017Article
- Pathophysiologic differences in cerebral autoregulation after subarachnoid hemorrhage.Neurology · 2016Article
- Impaired Cerebral Autoregulation during Head Up Tilt in Patients with Severe Brain Injury.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired cerebral autoregulation (CA) is increasingly recognized to contribute to sequelae after aneurysmal subarachnoid hemorrhage (SAH). The current study characterizes the course of the dynamic autoregulation index (ARI) during the first 8 days after SAH and its coherence with angiographic vasospasm (VS) and clinical outcome.
methodsFifty-one patients with SAH were prospectively included within 48 h after the ictus. The ARI was determined daily for each hemisphere with the thigh cuff test. The degree of cerebral VS was evaluated based on a baseline digital subtraction angiography (DSA) after the ictus and a follow-up DSA on day 8. The clinical outcome was determined by the Modified Rankin Scale (mRS), the Glasgow Outcome Scale Extended (GOSE), and the National Institute of Health Stroke Scale (NIHSS) at discharge from the intensive care unit.
resultsImpaired CA significantly correlated with unfavorable clinical outcome scores (mRS, p = 0.0021; GOSE, p = 0.0027; NIHSS, p = 0.0091). ARI-values of patients with a favorable clinical outcome (mRS 0-3) showed a significant improvement during the first 8 days (+0.1964/day; p = 0.0148) compared to a significant decrease of ARI-values in patients with an unfavorable clinical outcome (-0.2976/day; p = 0.0182). The degree of CA impairment significantly correlated with the severity of VS in the middle cerebral artery (p = 0.0184).
conclusionsEarly deterioration of CA significantly correlates with unfavorable clinical outcome and severity of angiographic vasospasm. Dynamic CA measurements might represent an important tool in stratifying therapy guidelines in patients after SAH.
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