ArticleThe journal of physiological sciences : JPS2015
Neurophysiological modeling of bladder afferent activity in the rat overactive bladder model.
Article in The journal of physiological sciences : JPS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Exploratory research on efficacy and safety of a fine-needle tibial nerve stimulator for treating overactive bladder in cats.International urology and nephrology · 2026Article
- UROREC: A cystometry and electromyography recording system for analyzing urinary incontinence parameters in rat models.PloS one · 2026Article
- Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats.European journal of medical research · 2025Article
- Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array.APL bioengineering · 2023Article
- Can cardiac pressure-volume catheters improve urodynamic assessment? an ex-vivo proof-of-concept.Frontiers in urology · 2023Article
- Mathematical modeling of the lower urinary tract: A review.Neurourology and urodynamics · 2022Review
- Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.Toxics · 2022Review
- Psychological stress induced bladder overactivity in female mice is associated with enhanced afferent nerve activity.Scientific reports · 2021Article
- Molecular and functional characterization of detrusor PDGFRα positive cells in spinal cord injury-induced detrusor overactivity.Scientific reports · 2021Article
- Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines.Scientific reports · 2020Article
- Real-Time Bladder Pressure Estimation for Closed-Loop Control in a Detrusor Overactivity Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2019Article
- Article
- Hysteretic behavior of bladder afferent neurons in response to changes in bladder pressure.BMC neuroscience · 2016Article
- Inhibitory effects of tibial nerve stimulation on bladder neurophysiology in rats.SpringerPlus · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The overactive bladder (OAB) is a syndrome-based urinary dysfunction characterized by "urgency, with or without urge incontinence, usually with frequency and nocturia". Earlier we developed a mathematical model of bladder nerve activity during voiding in anesthetized rats and found that the nerve activity in the relaxation phase of voiding contractions was all afferent. In the present study, we applied this mathematical model to an acetic acid (AA) rat model of bladder overactivity to study the sensitivity of afferent fibers in intact nerves to bladder pressure and volume changes. The afferent activity in the filling phase and the slope, i.e., the sensitivity of the afferent fibers to pressure changes in the post-void relaxation phase, were found to be significantly higher in AA than in saline measurements, while the offset (nerve activity at pressure ~0) and maximum pressure were comparable. We have thus shown, for the first time, that the sensitivity of afferent fibers in the OAB can be studied without cutting nerves or preparation of single fibers. We conclude that bladder overactivity induced by AA in rats is neurogenic in origin and is caused by increased sensitivity of afferent sensors in the bladder wall.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.